Aims, Settings, and Design: The COVID-19 pandemic has forced upon sudden lifestyle changes because of nationwide lockdowns mandating isolation at home, affecting daily habits and lifestyle changes. The present study was conducted with an aim to assess these changes brought about because of COVID-19 lockdown restrictions. Methods: The web-survey aimed to understand the immediate impact of the COVID-19 lockdown on people by using a structured questionnaire collecting demographic, lifestyle, and dietary information. The survey was disseminated online among the literate, urban, adult population with internet access. Results: Of the 1,200 people who received the survey, a total of 1,008 respondents participated in the study, aged between 18 and 81 years (Median- 24). An increase in daily screen time has been observed in 56.7% of the population. A decrease in work-related stress was observed in 43% of the population, sleep pattern improved in 36.7% people, and 27.1% of the inactive population showed increased physical activity. A significant decrease in the proportion of people consuming junk food (73.8%), alcohol (27.6%), and smoking (8.1%) was observed. Conclusions: The present web-based survey study suggests a significant change in the lifestyle and dietary patterns of people brought about because of the COVID-19 lockdown most highly seen as a major increase in screen usage and a decrease in junk food consumption.

Context: Following rapid spread of COVID-19, WHO on March 11, 2020, declared COVID-19 a global pandemic. Diabetes is known to confer increased risk for various infections. Studies from outside India have shown more aggressive course of COVID 19 Pneumonia in diabetic patients. Material and methods:Aretrospective observational study was carried out at Mahatma Gandhi Medical College and Hospital, Jaipur. Data from electronic medical records of seven thirty-one patient admitted from 15 October 2020 to 30 November 2020 were reviewed and analysed Results: Patients with diabetes had signicantly higher need of oxygen therapy and ICU admission. No difference was observed in mortality rates in the two group of patients.Conclusion: Diabetes patients appear to be at higher risk of severe illness from COVID-19 than those without diabetes.

A bstract Purpose End-organ damage in coronavirus disease-2019 (COVID-19) is linked to “cytokine storm” and excessive release of inflammatory mediators. Various novel therapies have been used in COVID-19 including urinary trypsin inhibitor therapy. This study explores the efficacy of ulinastatin in COVID-19. Materials and methods We retrieved the medical records of patients admitted during one month and did a propensity score analysis to create matched treatment and control groups. We analyzed these groups and the outcomes were presented with appropriate statistics. Survival curve was prepared to compare the survival effect of ulinastatin therapy at the end of hospitalization, among both the groups. Results A total of 736 patients were admitted, and after adjusting the data with propensity score matching, 55 cases were selected by the system. On the final outcome analysis, we found that intensive care unit (ICU) length of stay [median (interquartile range) days 3 (3.5–7.8) vs 2 (0-4); p -value 0.28] in control vs intervention groups, and in hospital mortality (odds ratio: 0.491, CI 95%: 0.099–2.44, p -value 0.435) were not statistically different among the groups. In survival plot analysis also, there was no statistical difference ( p -value 0.414) among both the groups. Conclusion: In this retrospective study, we conclude that the final outcome of the ICU length of stay, and overall, in hospital mortality were not different among both the groups. Hence, adequately powered randomized control trials are urgently required to confirm any benefit of ulinastatin therapy in COVID-19 treatment. How to cite this article Jain A, Kasliwal R, Jain SS, Jain R, Gupta D, Gupta P, et al. Effect of Urinary Trypsin Inhibitor (Ulinastatin) Therapy in COVID-19. Indian J Crit Care Med 2022;26(6):696–703.

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Aims and Objectives: This study aims to assess the effects of COVISHIELD vaccine on humans after first dose of vaccination. In this study we have evaluated vaccine’s effect after first dose on health officials in central India.