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The authors present a case of a child who had severe dietary restriction with consumption of french fries only. He presented to the ophthalmology clinic with light perception vision in both eyes, and was found to have dry, leathery conjunctivae with Bitot's spots and hazy corneas with diffuse punctate epithelial erosions. Electroretinography testing showed an absent rod response and a decreased cone response. Laboratory testing results were positive for vitamin A deficiency. After prompt initiation of treatment, he had improvement in his vision and anterior segment findings. This case serves as a reminder that vitamin A deficiency can present in high-income countries, and that ophthalmologists may play a key role in diagnosing the condition, initiating treatment, and sending patients to the appropriate subspecialists for further evaluation and management of the underlying condition. For patients with vitamin A deficiency, ophthalmologists can play an essential role in preventing permanent vision loss and the systemic consequences of deficiency such as infection or death. [ J Pediatric Opthalmology & Strabismus. 2022;59(3):e35–e38.]

The purpose of this study was to examine the time course of changes in vascular reactivity and antioxidant status in rat aortas following an acute exhaustive bout of exercise. 7–9 mo old, male, Wistar rats were divided into four groups (n=9/group): sedentary (SED), 6 h post‐exercise (6 h), 24 h post‐exercise, and 48 h post‐exercise. Exercise consisted of one bout of exhaustive treadmill exercise lasting between 30–40 min. Endothelium dependent vasorelaxation was assessed in ring segments of the aorta by constructing an acetycholine (ACh) dose response curve (10−10–10−5 M) in a wire myograph.RESULTSMaximal vasorelexation was impaired in 6 h (67.7±5.4%) compared to SED (76.9±4.1%) and 24 h (80.2+5.5%). EC50 for ACh at 6 h (9.9±0.1e−7 M) was significantly (p<0.05) greater than SED (4.8±0.1e−7) and 24 h (3.9±0.1e−7). However, antioxidant capacity was not significantly (P<0.05) increased until 48 h post‐exercise (0.61±0.15 mM) compared to SED (0.14±0.05 mM). These data suggest that acute, exhaustive treadmill exercise results in impaired endothelial dependent vasorelaxation 6 h post‐exercise and returns and possibly improves within 24–48 h during which time antioxidant capacity is increased.Support or Funding InformationBorgenicht Program for Aging Studies and Exercise ScienceThis abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.