Heart Block After Coronary Artery Bypass???Effect of Chronic Administration of Calcium-Entry and ??-Blockers

Henling, C. E.; Slogoff, Stephen; Kodali, Sruthi; Arlund, Carolee

doi:10.1097/00132586-198502000-00043

Cited by 9 publications

(2 citation statements)

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“…As tachycardia was correlated with ischaemic episodes 164 the inclusion of patients administered different CCB in the CCB groups could have led to methodological bias. Henling et al 167 showed that the preoperative administration of betablocker with CCB was not accompanied by a greater incidence of conduction disturbances.…”

Section: Myocardial Ischaemiamentioning

confidence: 99%

Calcium-channel blockers and anaesthesia

Durand¹,

Lehot²,

Foëx

1991

Can J Anaesth

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Section: Myocardial Ischaemiamentioning

confidence: 99%

Calcium-channel blockers and anaesthesia

Durand¹,

Lehot²,

Foëx

1991

Can J Anaesth

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“…In patients post coronary bypass surgery, Henling and others [125] found that the risk for developing a heart block with either a beta blocker or a calcium antagonist alone or in combination with each other was very low and concluded that this should not be a factor in prescribing the treatment.…”

Section: Supraventricular Arrhythmiamentioning

confidence: 99%

Calcium channel antagonism and beta blockade in combination—A therapeutic alternative in cardiovascular disorders. A review

Lessem

Singh

1989

Cardiovasc Drug Ther

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Calcium-channel antagonists and beta-adrenergic blocking agents have become important modalities in the cardiovascular therapeutic armamentarium. These drugs are often administered as monotherapy to a wide range of cardiological patients with angina pectoris, hypertension, arrhythmias, congestive heart failure, and other diseases. Since within each class these drugs exhibit pharmacologic differences, it follows that their effectiveness varies in different disease states and that they exhibit a wide variety of side effects. In an attempt to optimize therapy, the individual drugs from these two classes can be combined; and the efficaciousness and side-effect profile of various combinations between calcium-channel antagonists and beta blockers are discussed in this review. Recommendations as to which patients may benefit from a combination and as to which patients may be harmed by the combination therapy will be made. Very few studies have compared the safety and efficacy of a single agent with the combination and with placebo in a controlled randomized fashion. To determine which therapy is superior and to determine which combination one should recommend under what circumstances, such placebo-controlled, randomized trials are a necessity, and will hopefully be performed although the complexity is enormous.

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Effects of beta-blockers and Ca2+ -antagonists on the response of the isolated working rat heart to adrenergic stimulants after cardioplegic arrest

Hattingh

Coetzee

Harper

et al. 1993

Cardiovasc Drug Ther

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During coronary artery bypass graft (CABG) surgery, patients pretreated with the combination of beta-blocking drugs and Ca2+ antagonists for control of myocardial ischemia often respond inadequately to adrenergic stimulants administered after cardioplegic arrest. In this study, the effects of the combination of a beta-blocker (propranolol) and a Ca2+ antagonist (nifedipine) on the spontaneous recovery, as well as the adrenergic response of the isolated, perfused, working rat heart after a period of cardioplegic arrest were evaluated. After pretreatment of the animals with propranolol and/or nifedipine, hearts were removed, perfused in the presence of pretreatment drugs, subjected to 45 minutes of normothermic cardioplegic arrest, reperfused, and finally stimulated with exponentially increasing concentrations of a sympathomimetic drug. Propranolol, and to a lesser extent nifedipine, protected the hearts during cardioplegic arrest, as indicated by the improved recovery and maximum response to adrenergic stimulation after cardioplegia. Isoprenaline, a beta-stimulant, (at a 100 x higher than conventional concentration), elicited an adequate inotropic and chronotropic response. Stimulation by the alpha, beta-stimulant adrenaline or dobutamine improved only the inotropic response of propranolol and combination treated hearts. Cautious extrapolation of the results to human may suggest continuation of drug therapy of patients before CABG surgery.

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Heart Block After Coronary Artery Bypass???Effect of Chronic Administration of Calcium-Entry and ??-Blockers

Cited by 9 publications

References 0 publications

Calcium-channel blockers and anaesthesia

Calcium-channel blockers and anaesthesia

Calcium channel antagonism and beta blockade in combination—A therapeutic alternative in cardiovascular disorders. A review

Effects of beta-blockers and Ca2+ -antagonists on the response of the isolated working rat heart to adrenergic stimulants after cardioplegic arrest

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