Dithiolopyrrolones (DTPs), such as holomycin, are natural products that hold promise as scaffolds for antibiotics as they exhibit inhibitory activity against antibiotic-resistant pathogens. They consist of a unique bicyclic core containing a disulfide that is crucial for their biological activity. Herein, we establish the DTPs as prochelators. We show that the disulfides are reduced at cellular gluathione levels. This activates the drugs and initiates interactions with targets, particularly metal coordination. In addition, we report an expedient synthesis for the DTPs thiolutin and aureothricin, providing facile access to important natural DTPs and derivatives thereof.

Silicon-on-insulator technologies are well suited for high temperature circuit design, due to low leakage currents. The reduction of leakage currents is especially important in large repetitive structures such as memories. This paper describes the layout development of a high temperature SRAM cell in a SOI Technology. First, the differences between SOI technologies and standard CMOS processes are presented. It is then discussed, how SOI specific circuit element behavior affects the layout design of different parts of the SRAM cell. Solutions for SOI specific problems are presented and advantages and disadvantages of SOI technologies in static random access memory design are shown.

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