For the preparation of regioselectively N-substituted indolocarbazole alkaloids two strategies have been employed: 1. the exploitation of different electronic situations at the nitrogen atoms, and 2. the utilization of an orthogonal protecting group strategy that allows regioselective glycoside formation.

Complete Regioselectivity in Staurosporine Chromophore Formation.-The synthesis of compounds such as (VII) related to staurosporine is reported and their PKC-inhibition efficiency is discussed. However, none of them can compete with staurosporine itself. -(EILS, STEFAN; WINTERFELDT, EKKEHARD; Synthesis (1999) 2, 275-281; Inst. Org. Chem., Univ. Hannover, D-30167 Hannover, Germany; EN)