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This paper presents an optimization-based solution approach for the dynamic multi-level capacitated lot sizing problem (MLCLSP) with positive lead times. The key idea is to solve a series of mixed-integer programs in an iterative fix-and-optimize algorithm. Each of these programs is optimized over all real-valued variables, but only a small subset of binary setup variables. The remaining binary setup variables are tentatively fixed to values determined in previous iterations. The resulting algorithm is transparent, flexible, accurate and relatively fast. Its solution quality outperforms those of the approaches by Tempelmeier/Derstroff and by Stadtler.

MLCLSP-L is a big-bucket model that allows the production of any number of products within a period, but it incorporates partial sequencing of the production orders in the sense that the first and the last product produced in a period are determined by the model. We solve a model which is applicable to general bill-of-material structures and which includes minimum lead times of one period and multi-period setup carry-overs. Our algorithm solves 1 a series of mixed-integer linear programs in an iterative so-called Fix-andOptimize approach. In each instance of these mixed-integer linear programs a large number of binary setup variables is fixed whereas only a small subset of these variables is optimized, together with the complete set of the inventory and lot size variables. A numerical study shows that the algorithm provides high-quality results and that the computational effort is moderate.

We present a detailed analysis of the patient and resource scheduling problem in rehabilitation hospitals. In practice, the predominantly therapeutical treatments and activities which are prescribed for the patients are typically scheduled manually.This leads to rigid and inefficient schedules which can have negative effects on the quality of care and the patients' satisfaction. We outline the conceptual framework of a decision support system for the scheduling process that is based on formal optimization models. To this end, we first develop a large-scale monolithic optimization model. Then we derive a numerically tractable hierarchical model system in order to deal with problem instances of realistic sizes. We report numerical results with respect to solution times, model sizes and solution quality.

Suggested Citation: Helber, Stefan; Sahling, Florian; Schimmelpfeng, Katja (2011) AbstractWe present a stochastic version of the single-level, multi-product dynamic lotsizing problem subject to a capacity constraint. A production schedule has to be determined for random demand so that expected costs are minimized and a constraint based on a new backlog-oriented δ-service-level measure is met. This leads to a non-linear model that is approximated by two different linear models. In the first approximation, a scenario approach based on random samples is used. In the second approximation model, the expected values of physical inventory and backlog as functions of the cumulated production are approximated by piecewise linear functions. Both models can be solved to determine efficient, robust and stable production schedules in the presence of uncertain and dynamic demand. They lead to dynamic safety stocks that are endogenously coordinated with the production quantities. A numerical analysis based on a set of (artificial) problem instances is used to evaluate the relative performance of the two different approximation approaches. We furthermore show under which conditions precise demand forecasts are particularly useful from a production-scheduling perspective.