The mechanical properties and hydraulic permeabilities of biomaterial scaffolds play a crucial role in their efficacy as tissue engineering platforms, separation processors, and drug delivery vehicles. In this study, electrospun cellulose acetate fiber meshes of random orientations were created using four different concentrations, 10.0, 12.5, 15.0, and 17.5 wt % in acetone or ethyl acetate. The tensile mechanical properties and the hydraulic permeabilities of these meshes were measured, and a multiscale model was employed to predict their mechanical behavior. Experimentally, the elastic modulus ranged from 3.5 to 12.4 MPa depending on the polymer concentration and the solvent. Model predictions agreed well with the experimental measurements when a fitted single-fiber modulus of 123.3 MPa was used. The model also predicted that changes in fiber alignment may result in a 3.6-fold increase in the elastic modulus for moderately aligned meshes and a 8.5-fold increase for highly align meshes. Hydraulic permeabilities ranged from 1.4 x 10(-12) to 8.9 x 10(-12) m(2) depending on polymer concentration but not the choice of solvent. In conclusion, polymer concentration, fiber alignment, and solvent have significant impact on the mechanical and fluid transport properties of electrospun cellulose acetate fiber meshes.

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Abstract:The need to manufacture a copy of a mechanical part typically arises when a single replacement part is necessary and is out of stock or out of production altogether. For parts with intricate details and associated accuracy requirements, investment casting may be preferred to machining, for size and detail reasons, or 3D printing, for material reasons. This work applies the digital manufacturing paradigm to one-off vacuum-aided rapid investment casting focusing on the process chain rather than on engineering issues. 3D laser scanning, digital model construction by surface fitting, casting model making by exploiting additive manufacturing, material investigation using scanning electron microscopy, casting simulation exploring process parameter scenarios, as well as the corresponding implementation on a vacuum casting machine are the pertinent interlinked steps and techniques. The added value of this work is that for each process link the important steps and the potential pitfalls are analyzed in detail using as an example a cylinder liner from a model car engine. Quality of the result was quite acceptable, the main benefit of the streamlined approach being that "right-first-time" parts can be achieved.