This review is devoted to the urgent problem of modern oncology - combined treatment of locally advanced lung cancer with neoadjuvant chemotherapy, chemoradiation, targeted therapy. Literature data on the influence of various variants of neoadjuvant therapy on the development of postoperative bronchopleural complications, risk factors, methods of their prevention are analyzed in detail. The role of primary and secondary plastics of the stump of the main bronchus, tracheobronchial anastomoses with various autoflaps is highlighted. The article analyzes the data of large meta-analyzes and works originating from specialized clinics dealing with this problem.

The analysis of long-term results of surgical treatment of 198 patients with non-small cell lung cancer (NSCLC) I -III stages. Bronchoplasty (BP) interventions were performed in 99 cases, the control group comprised 99 patients after pneumonectomies (PE) corresponding to the main prognostic criteria for patients after BP interventions. A 1-year, 3-year and 5-year observed survival rates of patients were 87.7%, 56.2% and 44.6% after BP versus 82.8%, 54.6% and 35.9% after PE, respectively. A 1-year, 3-year and 5-year disease-free survival in the BP group was 87.9%, 64.2% and 52.3% versus 88.1%, 61.6% and 37.9% in the PE group. The median of overall and disease-free survival was 51.4 and 55.2 months in the BP group versus 46.2 and 41.0 months in the PE group, respectively.