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We have searched for genes predisposing to bipolar disorder (BP) by studying individuals with the most extreme form of the affected phenotype, BP-I, ascertained from the genetically isolated population of the Central Valley of Costa Rica (CVCR). The results of a previous linkage analysis on two extended CVCR BP-I pedigrees, CR001 and CR004, and of linkage disequilibrium (LD) analyses of a CVCR population sample of BP-I patients implicated a candidate region on 18p11.3. We further investigated this region by creating a physical map and developing 4 new microsatellite and 26 singlenucleotide polymorphism markers for typing in the pedigree and population samples. We report the results of fine-scale association analyses in the population sample, as well as evaluation of haplotypes in pedigree CR001. Our results suggest a candidate region containing six genes but also highlight the complexities of LD mapping of common disorders.

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The ecosystem services concept has emerged as a guiding principle in natural resource management over the past two decades, and an ecosystem services approach to management is currently mandated as a core element of United States National Forest planning. However, the concept of ecosystem services has been interpreted and operationalized in a variety of ways, leaving a pronounced knowledge gap regarding how it is understood and implemented in different contexts. To better understand the conceptualization and implementation of the concept within United States National Forests, semi-structured interviews with planners and managers of the Pacific Northwest Region were conducted at the region, forest, and ranger district levels, addressing the following topics: (1) how has the ecosystem services concept been perceived by managers and planners?; (2) what are the perceived key ecosystem services offered by National Forest lands?; (3) how has the concept been applied at multiple spatial scales?; and (4) what are perceived challenges or opportunities related to applying the concept in the National Forest context? Results indicate that although participants had a high level of understanding of the ecosystem services concept, there was not a clear, widely adopted approach to considering ecosystem services in management. Through qualitative analysis, three general perspectives arose: one employed the concept to fulfill regulatory requirements at the National Forest scale, a second engaged with ecosystem services to improve participatory planning at the project scale, and a third, business as usual perspective, considered ecosystem services as new language for describing longstanding National Forest priorities. These results draw attention to the challenges of implementing an ecosystem services-based approach in the United States National Forest context and the continued need for the development of management-relevant methods for describing and quantifying ecosystem services.