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In Reply First of all, we would like to thank Dr Ghadami for his interest and comments on our research. 1 And also, we agree with his opinion that sleep problems may contribute to the development of depression and anxiety in patients with chronic rhinosinusitis (CRS). Importantly, as we emphasized in our research, we found that patients with CRS without nasal polyp showed a higher risk of developing depression and anxiety than those with CRS with nasal polyps. However, we could not compare the degree of sleep impairment between patients in the 2 groups because the database used does not provide information from sleep-related medical charts or polysomnography data. For these reasons, we could not suggest sleep problems as a possible cause in this study.

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