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In a ‘triple blind’ study on 30 subjects, 50 mg diethylpropion was compared with 10 mg dexamphetamine, 50 mg phenmetrazine, 250 mg caffeine, and placebo. The effects were measured in 5 subjective variables at 40 minutes intervals up to 4 hours. Clear trends were obtained in ‘happiness’, ‘alertness’ and ‘pleasantness’. Peak effects were seen at about two hours, but in pleasantness the effects of phenmetrazine were increased even after that time. The demonstrated effects were discussed in relation to data on abuse of diethylpropion and phenmetrazine.

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