Sulfatinib is a small molecule kinase inhibitor that targets tumor angiogenesis and immune modulation. This phase I study (NCT02133157) investigated the safety, pharmacokinetic characteristics, and preliminary anti-tumor activity of sulfatinib in patients with advanced solid tumors. The study included a dose-escalation phase (50-350 mg/day, 28-day cycle) with a Fibonacci (3+3) design, and a tumor-specific expansion phase investigating the tumor response to treatment. Two sulfatinib formulations were assessed: formulation 1 (5, 25, and 50 mg capsules) and formulation 2 (50 and 200 mg capsules). Seventy-seven Chinese patients received oral sulfatinib; the maximum tolerated dose was not reached. Dose-limiting toxicities included abnormal hepatic function and coagulation tests, and upper gastrointestinal hemorrhage. The most common treatment-related adverse events were proteinuria, hypertension and diarrhea. Among 34 patients receiving sulfatinib formulation 2, one patient with hepatocellular carcinoma and eight with neuroendocrine tumors exhibited a partial response; 15 had stable disease. The objective response rate was 26.5% (9/34) and the disease control rate was 70.6% (24/34). Pharmacokinetic, safety, and efficacy data supported continuous oral administration of sulfatinib at 300 mg as the recommended phase II dose. Sulfatinib exhibited an acceptable safety profile and encouraging antitumor activity in patients with advanced solid tumors, particularly neuroendocrine tumors.

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Grey relational method is a data process method used to sort out the correlation extent of influence factors in a system with uncertain information. In this paper, it is applied to evaluate the effect of environmental factors on Atmospheric corrosion of Aluminum alloys and find out the main factors. Analysis results indicate that the influence order of the meteorological factors in atmospheric corrosion exposing for one year, three years, six years and ten years is always the same: Fog﹥RH﹥Humidity over 80%﹥Rain﹥T﹥Precipitation﹥Dew. But for pollutant factors, the sorted result is changeable at different exposure time. The effect of , is obvious all the time, and plays an important role in the initial stage of corrosion, yet is turned to be the dominant factor with increase of the exposure time.

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In this study, single factor experiment and orthogonal experiment were used to study the extraction effect of carotenoids from navel orange in southern Jiangxi Province assisted by ultrasonic technology. The experimental results showed that when hexane: ethanol=1:1 as the extraction agent, liquid to solid ratio of 1:30, extraction time of 8 min, ultrasonic power of 250 W, extraction temperature of 25°C, extraction times of 4 times, the best extraction effect of carotenoids from Gannan navel orange was obtained.