Whenever the bacterium Acinetobacter Baumannii is mentioned the antimicrobial agents resistance come directly into the mind. This bacteria have been widely distributed worldwide since it have the ability to maintain their living in any surrounding niches including the harsh ones.(Lin, 2014).Being resistant made it a problematic pathogen that makes therapists unable to treat their patients because some of Acinetobacter Baumannii strains are extensively multidrug resistant(XDR) (Moubareck and Halat, 2020)A. Baumannii is characterized as Gram negative coccobacilli has the ability to produce catalase but lacking oxidase and fail to ferment glucose.(Kamali et al., 2020)A. Baumannii can cause wide range of infections comprising various body systems, of which respiratory tract, urinary tract, skin, and blood.(Nwadike, Ojide and Kalu, 2014)

Coronavirus disease 19 (COVID-19), is acute aspiratory syndrome caused by coronavirus 2 (SARS-CoV-2). Factors such as age, health status (cardiovascular disease, diabetes) and gender are the most important risk factors in terms of their relationship to the host ability to infected with COVID-19. However, the genetic association evidence has been unclear yet in our population. This study, demonstrated genetic predisposition investigation to detect SNPs allele locus 3p21.31at of rs11385942   associations with COVID-19 infection. Statistical analysis and DNA sequences analysis were conducted to the study cases. The results showed male incidences is higher than female number (60 cases- 60% male) corresponding (40 cases40% female). COVID-19 impact significantly on C-reactive protein and the age group 55-65 appeared high level of CRP (130.5 ± 58.93).  While, DNA sequence using Sanger sequencing method with further alignments analysis showed the association signal at locus 3p21.31 genes homozygous allele AA/AA frequent exist for the rs11385942 as risk allele in sever patients who have diabetes type 1 or 2 and received oxygen supplementation. However, no heterozygous alleles mutant was detected  To conclude, that aged patients and male paralleled the severity of COVID-19.

Coronavirus disease (COVID-19) is a pandemic caused by new beta-coronavirus SARS-CoV-2.  Recently, several studies provided evidences to confirm that factors such as blood group type and the genetic variations play a significant role in severe infection. The current study focused on ABO blood group type and genetic suitability. 100 (male & female) sample were collected. The number of infected males was higher than female number (60% male), while the females were (40 %), the highest number of patients within age group 25-35 cases in male. while female showed the highest percentage infection in the age group 15-25. The blood group A among patients with was significantly higher 34 %. While the lowest proportion of blood group AB. We applied Sanger sequencing method to identify the genetic variation distribution patterns of single nucleotide polymorphisms regions of the ABO genetic locus rs657152 at the 9q34.2c. Initially, genomic DNA was extracted successfully for all cases followed amplification ABO gene locus, further alignment of sequences samples against a Homo sapiens in the NCBI showed two mutants type SNPs for mostly A/C and C/C associated sever infection corresponding the sequence the control A/A.