Increased levels of violence and sexual abuse of children in Malang Regency, and the process of development of the child, where at the age of 9-12 years old children begin pubert, the elementary school child needs to get sexuality education. Sexuality education would be better if given according to the needs of children. The purpose of this study is to analyze the needs for sexuality education at primary school children in Gondanglegi Sub-District. This study used quantitative method, explanatory research with cross sectional approach. Data collection using questionnaires on 317 samples at 24 elementary schools. Data analysis using univariate, with chi-square bivariate and multivariate logistic regression. Results showed that the majority of respondents (70.03%) require sexuality education with avariables effect on sexuality education needs is information (OR =4,870), knowledge (OR =3,028), and attitudes toward sexuality education (OR =4,271). ABSTRAKSemakin tingginya kekerasan dan pelecehan seksual pada anak di wilayah Kabupaten Malang serta adanya proses tumbuh kembang anak, dimana pada usia 9-12 tahun anak mulai memasuki masa pubertas, maka anak sekolah dasar perlu mendapatkan pendidikan seksualitas. Dan pendidikan seksualitas akan lebih baik jika diberikan sesuai kebutuhan anak.Tujuan dari penelitian ini adalah menganalisis kebutuhan pendidikan seksualitas pada anak sekolah dasar di Kecamatan Gondanglegi Kabupaten Malang.Metode penelitian yang digunakan adalah metode kuantitatif dengan rancangan explanatory research dengan pendekatan cross sectional. Pengumpulan data menggunakan kuesioner pada 317 sampel pada 24 sekolah dasar. Analisa data secara univariat, bivariat dengan chi-square dan multivariate dengan regresi logistik.Hasil penelitian menunjukkan bahwa sebagian besar responden (70.03%) membutuhkan pendidikan seksualitas dengan variabel yang berpengaruh pada kebutuhan pendidikan seksualitas adalah informasi (OR= 4.870), pengetahuan (OR=3.028), dan sikap terhadap pendidikan seksualitas (OR= 4.271).

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Frekuensi kejadian mola hydatidosa yang berpotensi menjadi penyakit trofoblast ganas terus meningkat. Mekanisme patologis yang mendasari penyakit tersebut belum dapat dieksplorasi secara mendalam, terdapat pemikiran bahwa mekanismenya terkait dengan kerusakan oksidatif yang berhubungan dengan produksi reactive oxygen species (ROS). Diketahui bahwa hormon estrogen dan metabolitnya dapat memproduksi ROS, untuk itu perlu dianalisis seberapa jauh keterlibatan estrogen (17βestradiol) dalam patomekanisme penyakit ini melalui pengukuran total ROS. Penelitian ini dilaksanakan secara eksperimental dengan menggunakan randomized group control design. Rancangan percobaan yang digunakan adalah rancangan acak lengkap dengan 1 kelompok perlakuan, yaitu kelompok kultur jaringan mola hydatidosa yang mendapat suplementasi estrogen (17β-estradiol) dalam 4 dosis (5 g/ml, 10 g/ml, 20 g/ml, 40 g/ml) dan tanpa suplementasi. Dari hasil penelitian didapatkan perbedaan sangat bermakna kadar ROS antara kelompok kontrol dengan kelompok 17β-estradiol 5 g/ml dan 17β-estradiol 40 g/ml (p = 0,000 < 0,05), antara kelompok perlakuan 17β-estradiol 10 g/ml dan 17β-estradiol 40 g/ml (p = 0,000 < 0,05) dan antara kelompok perlakuan 17β-estradiol 20 g/ml dan kelompok perlakuan 17βestradiol 40 g/ml (p = 0,000 < 0,05). Disimpulkan bahwa pemberian 17β-estradiol 20 g/ml dan 40 g/ml mempengaruhi produksi total ROS pada kultur jaringan mola hydatidosa. Kata kunci: 17β-estradiol, mola hydatidosa, reactive oxygen species (ROS).

Embryonic cell carcinoma (EC) is the first pluripotent cell identified and originates from a germ cell tumor called teratocarcinoma. Although rare, embryonal carcinoma is one of the most malignant cancers that can be found in the ovary. In this case report, a 4.5 year old girl was diagnosed with embryonal ovarian carcinoma after experiencing menstrual complaints for three months and developing pubic hair and breasts. Then the patient underwent a limited staging laparotomy. The results of clinical examination, radiology, and anatomical pathology showed results according to embryonal ovarian cancer. Chemotherapy with bleomycin etoposide and cisplatin for 3 cycles at 3 week intervals was performed after surgery. From this case, it can be concluded that physical examination and other examination are needed to diagnose embryonic ovarian cancer correctly.

Diabetes Mellitus is a chronic disease caused by abnormal working insulin, insulin secretion or both so that the body tends to have high glucose levels. Type 2 diabetes mellitus can cause elevated levels of LDL and cholesterol. Risks obtained by fetuses with type 2 diabetes can be in the form of macrosomia due to hyperglycemia and hyperinsulin in the body of the fetus. Insulin is the first choice pharmacological therapy for type 2 DM that can be given during pregnancy. Non-pharmacological therapy as recommended by the World Health Organization (WHO) on a healthy diet by increasing consumption of fruits and vegetables. Good fruit consumed for pregnant women with diabetes mellitus (DM) type 2 is tomatoes (Solanum lycopersicum L). The purpose of this study was to determine the administration of tomato extract (Solanum lycopersicum L) and insulin can affect glucose levels, LDL levels, cholesterol levels and birth weight of white wistar galur (Rattus norvegicus) pregnant women with type 2 diabetes mellitus models. experimental design using the pre post test only control group design and post test only control group design. Termination was done on the 17th day of pregnancy and then followed by measurements of LDL levels, cholesterol and birth weight. Data analysis using the One Way Anova test and Kruskal Wallis then continued with the Post Hoc test using. The results showed that there were significant differences between glucose levels, LDL levels, cholesterol levels and BW born in the insulin treatment group and the tomato juice treatment (p value = 0.00 <α = 0.05). The conclusion of giving insulin and tomato juice affects a decrease in glucose levels, LDL levels, cholesterol levels and birth weight.