Durian is a fruit that is in demand by the community, but during durian season environmental problems arise due to waste from skin of durian. The aimed of the study was to prove the antifungal activity of the ethanol fraction of durian skin against Trichophyton mentagrophytes and Candida albicans and to determine the active active compounds inhibiting T. mentagrophytes and C. albicans fungi. Durian skin was extracted by maceration method, then fractionated used ethanol, chloroform, and n-hexane solvents. Ethanol fraction was tested on T. mentagrophytes and C. albicans fungi used the disc method with a concentration of 10%, 20%, 40%, 60%, 80%, 100%, distilled water as a negative control, ketoconazole as a positive control. The best inhibition zone is fungi T. mentagrophytes concentration 100% ( 9.23 mm) negative control (0 mm), positive control (32.96 mm), fungi C. albicans the best inhibition zone is concentration of 100% (8.30 mm), positive control (17.17 mm) negative controls (0 mm).The ethanol fraction was screened by the Thin Layer Chromatography method and positively contained flavonoids (rf 0.7), tannins (rf 0.58), saponins (rf 0.76) and alkaloids (rf 0.64). Minimum Inhibitory Concentrations of T. mentagrophytes were 7% and C. albicans were 8%. The most effective active compound growht of T. mentagrophytes is tannins (rf 0.7) and for C. albicans is flavonoid (rf 0.6). The ethanol fraction of durian bark extract has antifungal activity against T. mentagrophytes and C. albicans. Keywords: Antifungi, Candida albicans, ethanol fraction skin of durian, Trichophytonmentagrophytes

Hypertension is a disease that contributes to death by 29.8%, factors that cause an increase in the prevalence of hypertension include patient compliance, compliance itself is influenced by one's behavior factors, one of which is knowledge. This study aims to look at the effect of the level of knowledge on the compliance of taking drugs with hypertension in Roworejo Public Health Center, Pesawaran Regency, Lampung. This research is a descriptive analysis research, conducted by giving a questionnaire that has been tested for validity and reliability and has obtained ethical permission from the ethics committee of Malahayati University, Bandar Lampung with No.485 / EC / Kep-UNMAL / VII / 2019. The level of compliance with drug taking can be seen from the recap of prescriptions for hypertension in April-June 2019. The category of adherence level uses the formula MPR (Medication Possession Ratio) which is <80% categorized as non-compliant and> 80% categorized as compliant. The data is then analyzed using linear regression, if the significant value <0.05 means that there is an influence between the variable X on the Y variable, if the significant value> 0.05 means that there is no influence between the variable X on the Y variable. The results showed that the most hypertensive patients aged> 60 years 81%, female sex 59%. The level of knowledge of the respondents mostly had medium knowledge 98% and high knowledge 2%. The level of compliance with respondent's drug taking was only 3% of respondents who were compliant and 97% of respondents were not compliant From the results of linear regression analysis in this study showed that the value of Significant value 0.000> 0.05, which can be concluded that there is an influence between the variable level of knowledge of the level of compliance with drug taking. Keywords: Hypertension, Compliance with drug uptake, Knowledge, MPR, Roworejo.

Abtract Many Indonesian people do self-medication as an attempt to treat complaints / pain they experience, the benefit of self-medication is safe when used according to the rules, effective for eliminating complaints, cost efficiency, can play a role in making therapeutic decisions, self-medication is usually done to overcome complaints and minor illnesses that are often experienced by people, such as fever, pain, dizziness, cough, influenza, ulcers, intestinal worms, diarrhea, skin diseases and others. This study aims to determine the level of knowledge and behavior towards the use of influenza drugs and cough by self-medication in Muara Burnai I Village, Ogan Komering Ilir district. The research analyzed was descriptive observational. The sampling technique uses the accindental sampling method. The instrument used in this study was a questionnaire. The results of the analysis of the level of knowledge and behavior analysis showed that there was a relationship between the level of knowledge and the behavior of influenza drug use and cough by self-medication was analyzed using the Chi-Square test sample of 100 respondents. The results of this study indicate that 36% have high knowledge and 64% have low knowledge in self-influencing and cough swamedication while 43% have high behavior and 57% have low behavior in influenza and cough swamedication in Muara Burnai I Village, Ogan Komering Ilir District. Based on the Chi-Square test results showed that the value of p = 0,000 (0.05). Shows that there is a relationship between the level of knowledge and swamedication behavior in Muara Burnai I Village, Ogan Komering Ilir district. Keywords : Influenza and cough, drug use behavior, swamedication, knowledge level.

AbstrakBau badan manusia biasanya terjadi akibat adanya produksi berlebih dari kelenjar keringat dan adanya bakteri. Bahan aktif untuk mencegah bau badan adalah bahan kimia dari tawas atau natrium, tetapi memiliki efek negatif seperti iritasi kulit, penyakit Alzheimer, kanker prostat dan kanker payudara. Teknologi bahan alami untuk mengatasi bau badan telah dikembangkan sebagai bahan aktif dengan menggunakan ketimun (Cucumis sativus .L). Tujuan dari penelitian ini adalah untuk menghasilkan deodoran yang stabil dan berkualitas secara fisik dan juga mengembangkan penggunaan ekstrak ketimun sebagai antibakteri Staphylococcus epidermidis. Ekstraksi ketimun telah dilakukan dengan maserasi menggunakan etanol 70% selama 4 hari dan kemudian dibagi menjadi tiga formulasi ekstrak (5%, 10%, dan 20% (b / v)). Semua formulasi telah diuji zona penghambatan, organoleptik, homogenitas, pH, viskositas dan uji iritasi. Hasilnya, semua formulasi memenuhi persyaratan mutu fisik formulasi ekstrak dengan formulasi terbaik adalah kandungan ekstrak 20% yang mampu menghambat bakteri dengan zona hambat terbesar yaitu 26 mm. Selain itu, stabilitas dipercepat deodoran diuji selama 35 hari pada suhu kamar (28° C) dan 40° C. Hasil pengujian menunjukkan bahwa kestabilan ekstrak 10% memenuhi syarat kualitas fisik selama penyimpanan pada suhu kamar (28°C) dan suhu tinggi (40°C) selama 35 hari. Sedangkan pada ekstrak 20%, pada suhu tinggi (40°C) terjadi perubahan fisik yang ditandai dengan pengendapan. Kata kunci: ketimun, deodoran, antibakteri AbstractBody odor of human skin usually occur due to excessive production of sweat glands couples with the presence of bacteria. The active ingredient to prevent body odor are chemicals materials from alum or sodium in order to have negative effects such as skin irritation, Alzheimer disease, prostate and breast cancer. Natural materials technology has been development as an active agent by using cucumber (Cucumis sativus .L). The purpose of this research to conduct a deodorant roll on a stable and qualified physical quality and also develop the use of extract cucumber as an antibacterial Staphylococcus epidermidis. Cucumber extraction has been done by maceration with ethanol 70% for 4 days and then divided into three formulation extract (5%, 10%, and 20% (b/v)). All of the formulations has been tested by zone inhibition, organoleptic, homogenity, pH, viscosity and irritation test. The results given that all of the formulations meet the quality requirements of physical and the best formulation extract 20% able to inhibit bacterial by 26 mm as a largest diameter of the inhibitory zone. In addition the stability of deodorant roll on form were performed accelerated stability test for 35 days at room temperature (28°C) and 40°C. The test results indicate that the stability of the extract 10% qualified physical quality during storage at room temperature (28°C) and high temperature (40°C) for 35 days. While in the extract 20% at high temperature (40 o C) physical changes characterized by the deposition.