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Our aim was to determine the association of diabetes mellitus with ABO and Rhesus(Rh) blood groups. 100 blood samples were taken(50 healthy controls and 50 diabetic patients) and analysed for blood sugar(GODPOD method) and blood group(using standard antisera). Patients having fasting blood sugar>126mg/dl were considered diabetic. Statistical analysis was done using chi-square test. Frequency of blood group B was high in both patients(46%) and controls(44%). The order of distribution in both groups were similar(i.e B>O>A>AB). Blood groups A(16%) and O(36%) were more common in control groups whereas AB(8%) in diabetics. Rh positivie blood group was more frequent in diabetics than compared to controls. No association of blood group and Rh factor with diabetes mellitus was observed(p>0.05). Similarly genderwise association also could not be developed(p>0.05). No association existed between blood group and diabetes mellitus. Extensive study is needed to establish the correlation.

Background: Hypertension is a hallmark risk factor for coronary heart disease, cerebrovascular stroke, congestive heart failure, cardiac arrhythmia, cardiomyopahy and abnormal renal function. Free radicals are involved in the pathogenesis of hypertension by altering endothelial function via oxidative stress. Aims & Objective: To assess the level of antioxidant enzymes superoxide dismutase (SOD), Catalase, Glutathione peroxidase (GPX) and lipid peroxidation product malondialdehyde (MDA) in hypertensive patients. Materials and Methods: 100 hypertensive patients and 25 healthy controls were included. Serum levels of enzymes and MDA were estimated by spectrophotometric methods. Results: The level of antioxidant enzymes were significantly lower and MDA was significantly higher in hypertensive patients as compared to controls (p<0.05). For SOD, significant difference could not be obtained between controls and stage I hypertensives with drugs (p>0.05). We also compared the enzymes and MDA level within the hypertensive groups. Significant results were obtained (p<0.05, 0.01). On comparison between stage I and stage II hypertensive without and with drugs, we found that hypertensive patients on drug have significantly higher level of antioxidant enzymes and lower level of MDA than those without anti-hypertensive drugs (p<0.01). Conclusion: Our study shows that hypertension is associated with oxidative stress. Adequate control of blood pressure and antihypertensive therapy decrease the oxidative stress, improves antioxidant status and endothelial function.

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