Case control study of ABO blood group and Rhesus (Rh) factor in type 2 Diabetes Mellitus

Shrestha, Shailaza; Jha, Sudha; Deep, Gagan

doi:10.15373/2249555x/apr2014/196

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…Nevertheless, the frequency of blood group B was slightly higher among T2DM patients compared to the high frequency of nondiabetic patients with blood group O. A similar pattern of results was found by Shrestha et al (2014), whereby no association was found between the ABO blood group and T2DM, and blood group B appearing as the most frequent among diabetic patients (12). Mandal et al…”

Section: Discussionsupporting

confidence: 74%

ABO Blood Group and Its Associated Factors Among Type 2 Diabetes Mellitus Patients

Din¹,

Sopian²,

Tajuddin³

et al. 2022

MJMHS

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Introduction: ABO blood group can be associated with chronic diseases, for example, cancer and coronary heart disease, however it is not proven in Type 2 Diabetes Mellitus (T2DM). The aim of this study was to identify the association between the ABO blood group and disease control among T2DM patients at Kepala Batas, Penang. Methods: Approximately two mL vials of fresh blood were collected and typed using the tube method from 129 T2DM and 132 non-diabetic (control) patients, who visited the specialist clinic. The sociodemographic characteristics of the T2DM patients was analysed using descriptive analysis. The proportions of A, B, AB, and O blood groups among the diabetic and control patients were compared using the chi-square test. Any association between the ABO blood group and disease control was identified using the bivariate correlation test. Results: No significant association was found between the ABO group and T2DM patients (p = 0.152) when compared with the control group. However, blood group B was the most frequent among T2DM patients (33.3%) compared to blood group O within the control group (36.4%). Negative associations were observed between the ABO blood group and BMI (r = 0.098, p = 0.268), as well as the HbA1C value (r = -0.065, p = 0.464). Conclusion: No association was found between the ABO blood group and the associated risk factors (BMI and HbA1C). However, individuals with blood group B and risk factors, such as older age group, obesity, and high HbA1C value (more than 7.0%), should be monitored.

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Section: Discussionsupporting

confidence: 74%

ABO Blood Group and Its Associated Factors Among Type 2 Diabetes Mellitus Patients

Din¹,

Sopian²,

Tajuddin³

et al. 2022

MJMHS

View full text Add to dashboard Cite

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Association of ABO blood groups with type-2 diabetes mellitus and its complications

Biplab¹,

Shukla²,

Ak³

et al. 2018

jdmdc

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Background: As type 2 DM has posed challenging and formidable problem globally lots of scientific research work have been targeted and concepts are evolving every other day to unleash newer etiological factor in its causation and side by side risk factors so that proper aggressive strategy can be instituted to contain the disease at the very outset. Keeping these ideas in the back of our mind we embarked upon this small but compact path finding study. Methodology:The study conducted in the Dept. of Endocrinology, Medical College and Hospital, Kolkata. Patients suffering from Type-2 DM (diagnosed by ADA criterion) attending our diabetic clinic and diabetic patients admitted including the Dept. of Endocrinology and Internal Medicine were selected for this study. Study was conducted from March 2013 to December 2014. 276, Type-2 diabetic patients and 117 healthy control subjects among the relative of patients and volunteers were selected for this study to compare distribution of ABO blood groups. All the study subjects were selected by random sampling technique. ABO blood grouping (determined by using Tulip Diagnostic Kit). Screening of complications done by appropriate clinical examinations and laboratory investigations.Results: Total 276 patients with type 2 DM were included in this study. Of those 276 diabetic patients 152(55%) were male and 124(45%) were female. 117 healthy control subjects among the relative of patients and volunteers were selected for this study to compare distribution of ABO blood groups. Mean age of diabetic patient was 50.46(±10.38) and non-diabetic control subjects was 40.52(±12.21). Mean BMI was 24.18(±3.77) in diabetic subjects and was 25.40(±3.92) in control population. Chi-square statistical analysis among different blood groups between non-diabetic (n=111) and diabetic population (N=276) revealed no significant relationship of any blood group with type 2 DM (p˃0.05). But relative risk (RR) were calculated in reference to blood group O, it has been observed that slight increase of risk of developing type 2 DM among AB( RR 1.075), A(1.044) and B(1.033).With regards to distribution of patients (in number) with type 2 DM with different microvascular complications, Nephropathy was the most common complication observed among different blood groups (37.2% in B, 36.6% in O, 36.5% in A and 34.5% in AB).Further exploring the association between specific blood groups in type 2 diabetes subjects and microvascular complications, no significant association observed with type 2 DM and neuropathy, nephropathy and retinopathy (p˃0.05). However, taking blood group O as a reference group, Blood group AB (RR 0.583 and blood group A(RR0.698) were less likely to develop neuropathy compare to blood group O. However no difference in relative risk found for development of nephropathy and retinopathy. Conclusion:We found that person with O+ve blood group has least chance of developing Type 2 DM whereas subject with AB+ve blood group are more vulnerable to develop Type 2 DM. Therefore, the effects of blood group...

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Association between ABO Blood Groups and Type 2 Diabetes Mellitus: A Meta-Analysis

Cano

Esguerra

Batausa

et al. 2023

CDR

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Background: The role of the ABO blood group goes beyond immunohematology as there is accumulating evidence on its association with type 2 diabetes mellitus. However, findings regarding the relation have been contradictory and there is a need to determine the validity of claims. Objective: Evaluate the susceptibility of the ABO blood groups to type 2 diabetes mellitus. Method: The research design is a meta-analysis. An extensive search was done in PubMed, ScienceDirect, ResearchGate, and Google Scholar. Heterogeneity was determined through Cochran’s Q test and I2 index. Random-effects model was used to measure the risk ratio and confidence intervals. Evaluation of publication bias was done using the funnel plot method; further supported by Egger’s linear regression test and Begg’s test. Results: The relative susceptibility of ABO blood groups to type 2 diabetes mellitus differs for blood type A (Relative risk [RR] = 1.05, 95% CI, 0.93 to 1.18), blood type B (RR = 1.03, 95% CI, 0.91 to 1.18), blood type AB (RR = 1.25, 95% CI, 0.78 to 1.99), and blood type O (RR = 1.11, 95% CI, 0.82 to 1.48). The highest risk of acquiring the disease was seen in type AB individuals, while the lowest risk was seen in type B individuals. Conclusion: A significant association was found between ABO blood groups and type 2 diabetes mellitus. ABO phenotype can therefore be considered a possible risk factor or potential genetic determinant of the disease, which can be used to improve diagnosis and treatment.

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Case control study of ABO blood group and Rhesus (Rh) factor in type 2 Diabetes Mellitus

Cited by 4 publications

References 2 publications

ABO Blood Group and Its Associated Factors Among Type 2 Diabetes Mellitus Patients

ABO Blood Group and Its Associated Factors Among Type 2 Diabetes Mellitus Patients

Association of ABO blood groups with type-2 diabetes mellitus and its complications

Association between ABO Blood Groups and Type 2 Diabetes Mellitus: A Meta-Analysis

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