Anahtar KelimelerHipotiroidi; Hipertiroidi; Lipid Profili; Bastar'da Abstract Aim: Function of thyroid gland is regulating a wide array of metabolic activities which have direct impact on some parameters. The objective of this study was to see the effect of thyroid dysfunction on serum lipid profile parameters among the people of Bastar region. Material and Method: Blood samples were collected from 60 subjects. The blood was analyzed for the levels of thyroid stimulating hormone (TSH), tri-iodothyroinine (T3), tetra-iodothyronine (T4), free tri-iodothyronine (FT3), free tetraiodothyronine (FT4) by microplate immune enzymetric assay. Patients with thyroid dysfunction were categorized into hypothyroid and hyperthyroid with increased and decreased levels of TSH respectively. Levels of total cholesterol (TC), triacylglycerol (Tg), low density lipoprotein-cholesterol (LDL-C) and high density lipoprotein-cholesterol (HDL-C) were measured, and compared between normal and patients with thyroid dysfunction. Results: Elevated levels of TC, Tg, LDL-C, VLDL-C, TC/HDL ratio, and significantly decreased HDL-C were observed in hypothyroid patients. Hyperthyroid patients revealed low HDL-C levels with no significant changes in TC, Tg, LDL-C, VLDL-C, and TC/HDL ratio. Analysis of variance (ANOVA) showed the significant difference among all the groups and Tukey's honest test revealed the significant difference in the mean values of the biochemical parameters in all groups at 0.05 level of significance. Discussion: As there is a controversy regarding effect of thyroid dysfunction on lipid profile, the present work was conducted on thyroid dysfunction tribal patients of Bastar, and compared with the normal subjects. The study concluded increased lipid profile in hypothyroid subjects and found no effect on the lipid profile of hyperthyroid subjects.

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Background: Diabetes mellitus is an endocrinal disorder. Over production of reactive oxygen and nitrogen species thought to be involved in the initiation and development of vascular complications in diabetes. Increased levels of MDA, Vitamin E and Ceruloplasmin are the markers for oxidative stress in type 2 diabetes mellitus. The aim of the present study is to study the Antioxidant status in Type 2 Diabetes patients. Materials & Methods:This, case control study was conducted on 40 subjects. Among them 20 were controls, 20 were known Type 2 Diabetes patients. Patients with T2DM with other endocrinal disorders, patients on antioxidants, minerals and multivitamins as supplement form are excluded from the study. A laboratory investigations consisting of glucose, total cholesterol, triglycerides, HDLC, LDLC Vitamin E, MDA and Ceruloplasmin were carried out on fasting blood sample of subjects selected for this study. Results: In the present study, FBS, PPBS, MDA, Ceruloplasmin, total cholesterol and LDLC were significantly increased in T2DM cases and HDLC, Vitamin E was significantly decreased in cases when compared to controls. (p value <0.05). Conclusion:The findings of this study is in accordance to earlier studies, that there is an increased oxidative stress in diabetics compared to controls; and the oxidative stress further increases as diabetes to cardiovascular diseases. This study emphasizes the importance of assessing the antioxidant status in diabetes in addition to the markers of oxidative stress and lipid profile to formulate the specific therapies for early therapeutic intervention and better treatment of diabetes mellitus.

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