(Fig. 1A). Several natural fusion proteins are known that contain a cytochrome b 5 domain and a second redox-active domain. Examples include sulfite oxidase (2-4) and ⌬5 and ⌬6 fatty acid desaturases (5, 6) in animals, nitrate reductase in algae (7) and plants (8, 9), and flavocytochrome b 2 or lactate dehydrogenase (10) and ⌬9 fatty acid desaturase (11) in bakers' yeast. However, Ncb5or is the only member of the cytochrome b 5 superfamily known to contain three distinct domains. The function of the non-redox-active CS domain is presently unknown, although its primary sequence is distantly homologous to those in human heat shock protein 20 (HSP20, a co-chaperone of HSP90) and other CS family members (12).The cytochrome b 5 family includes two isoforms in vertebrates, one anchored to the membrane of the endoplasmic reticulum (Cyb5A) and the other anchored to the outer mitochondrial membrane (Cyb5B) (13). Membrane anchoring in Cyb5A and Cyb5B is accomplished by a hydrophobic C-terminal domain. The polar heme-binding domains of Cyb5A and Cyb5B have virtually identical folds with secondary structure elements occurring in the order ␤1-␣1-␤4-␤3-␣2-␣3-␤5-␣4-* This work was supported, in whole or in part, by National Institutes of Health Grant RO1 DK067355 (to H. Franklin Bunn and H. Z.) and by National Institutes of Health Centers of Biomedical Research Excellence-Protein Structure and Function award 5P20 RR17708 (to the University of Kansas, R. P. Hanzlik, P. I.). This work was also supported by American Heart Association Grant-in-Aid 0755879T (to B. R. G.

The downlink coverage probability of a cellular network, when the base station locations are modelled by a Poisson point process (PPP), is known when the desired channel is Nakagami distributed with an integer shape parameter. However, for many interesting fading distributions such as Rician, Rician shadowing, κ-µ, η-µ, etc., the coverage probability is unknown. κ-µ shadowed fading is a generic fading distribution whose special cases are many of these popular distributions known so far. In this letter, we derive the coverage probability when the desired channel experiences κ-µ shadowed fading. Using numerical simulations, we verify our analytical expressions.

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In this paper, we derive the data-aided Error Vector Magnitude (EVM) in an interference limited system when both the desired signal and interferers experience independent and non identically distributed κ-µ shadowed fading. Then it is analytically shown that the EVM is equal to the square root of number of interferers when the desired signal and interferers do not experience fading. Further, EVM is derived in the presence of interference and noise, when the desired signal experiences κ-µ shadowed fading and the interferers experience independent and identical Nakagami fading. Moreover, using the properties of the special functions, the derived EVM expressions are also simplified for various special cases.

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