Background: Cystic fluids encountered during routine FNA poses a diagnostic challenge to cytopathologists due to its low cell yield with high dispersal of cells on conventional centrifuged smears (CS). Cell Block (CB) technique enables retrieval of small tissue fragments from fluids, thereby providing scope for better morphology and material for ancillary techniques which help in improving the diagnosis. Aim:To compare the efficacy of CB versus CS, in cyto-diagnosis of cystic lesions. Methods:This observational study was conducted on a total of 50 fluid samples aspirated from cystic lesions during routine FNA and fluids aspirated peri-operatively from cystic ovarian lesions. Divided into two equal parts, one part was processed for CS and CB by Fixed Sediment Method and relevant immunohistochemistry was performed. CSs were categorized as positive for malignancy, benign diagnosis, Inadequate for opinion and suspicious for malignancy. CBs were categorized as; no material, Non-contributory (CS+, CB-), confirms the smear diagnosis and establishes a specific diagnosis. The comparison between CS and CB was analysed by Chi-square test & kappa test. Results:Out of the 50 cases, 35(70%) were given a benign diagnosis, 10 (20%) were positive for malignancy, 2(4%) were suspicious and 3(6%) were inadequate for opinion on CS. In CB out of 50 cases, 29 of them confirmed/established a diagnosis and 21 cases were non diagnostic / non-contributory. CB gave an improved diagnosis in 2 out of 10 (20% ) malignant cases and 2 out of 35 (5.7%) benign cases. ( p value = 0.00054, Kappa value =0.34) Conclusions: CBs complemented CS, more so in malignant lesions by preserved architecture. Aspirates from multiple sites of the cystic lesions (with/without radiological assistance) pooled as one specimen yielded better material for CBs and ancillary techniques like histochemistry and IHC.

Background:Oral lesions can closely resemble one another and hence it is important for the clinicians to be able to recognize the various conditions and if possible obtain a biopsy for a confirmatory pathological diagnosis. Aim:To study the type of common benign lesions of the oral mucosa and to evaluate the concordance of clinical and histopathological diagnosis. Materials And Methods:A retrospective study was carried out in a tertiary care hospital in South Bangalore during the period of two years from June 2016 to May 2018. The study included 50 cases of benign lesions of the oral cavity. The following parameters were analyzed age and sex distribution of the lesion, site of the lesion, clinical presentation and histopathological diagnosis. Data collected were analyzed. Results:Among the 50 cases, the age ranged from 6 to 70 years with a mean of 30.3 years. Most of the patients were females (68%) in their 3rd decade. The sites of involvement of various lesions were labial mucosa with lower lip more commoner than upper lip, followed by tongue, buccal mucosa and maxillary alveolus. The various clinical diagnosis of the lesions were mucus retention cyst, papilloma and pyogenic granuloma. Excision biopsy of these lesions confirmed most cases of mucus retention cyst, pyogenic granuloma and few cases of papilloma on histopathological examination. Rest of the cases were extravastion cyst, fibromyxoma, actinomycosis, lobular capillary hemangioma, hamartoma, angiolymphoid hyperplasia with eosinophils and keratosis without atypia. Conclusion:Benign lesions of the oral cavity mimic each other. Histopathological typing of the lesions is mandatory to rule out malignancy and for a definitive and a confirmatory diagnosis.

Introduction: Para adnexal cysts (paraovarian and paratubal) constitutes a homogenous group of cystic lesions originating from mesosalphinx or broad ligament, located in proximity of the fallopian tube and ovary. As with the lesions of the adnexa, paraovarian and paratubal cysts can be neoplastic but are often misinterpreted as true functional cysts. A correct radiological and clinical diagnosis would be useful in order to render necessary treatment. Aim: To highlight the histomorphologic spectrum of the paraadnexal cysts and correlate with clinical findings. Materials and Methods: The present study was a descriptive study conducted in the Department of Pathology, Rajarajeswari Medical College, Bengaluru, Karnataka, India over a period of two years six months. All specimens including salpingoophorectomy specimens which harboured paratubal or paraovarain cysts, or paratubal/paraovarian cysts diagnosed on radiology and resected and sent separately for histopathologic evaluation were sampled and included in the study. All surgically and radiologically proven paratubal and paraovarian cystic lesions were included and solid lesions were excluded. The results were analysed using descriptive statistics. Results: The mean age of diagnoses was 40.1 years and menstrual abnormalities was the most common presentation. Of the Neoplastic cysts, paraovarian cysts (78.6%) were more common than paratubal cysts (21.4%). About 75.4 % were non neoplastic cysts and 24.6% were neoplastic. Conclusion: Para adnexal cysts are often misdiagnosed or not sampled as they are thought of as functional cysts. Present study analysed 114 cases and found that 28 of the cases showed neoplastic cysts, one of them showing a serous borderline tumour, which have the potential to turn malignant. Hence, histopathologic evaluation of these lesions would help in understanding the different histological types that would arise in para adnexal sites which in turn helps in better management of these patients.