Objective: This study was conducted to show Neuroprotective effect of aqueous extract of Centella asiatica in scopolamine induced cognitive impairment in mice. The improvement of cognitive impairment with Centella asiatica was compared against standard drug (Donepezil 50 µg/kg). Methods: Swiss albino mice (20-25 g) of either sex were randomly divided into 5 groups of 6 animals each. All the animals except the control group, received scopolamine (0.05 mg/kg) for 14 days.