<p class="Abstract"><em>Cadaba indica</em>, a component of traditional siddha medicine, is used for the therapy of gonorrhea, inflammation, eczema etc. The present study shows that it exhibited acetylcholinesterase inhibitory activity (up to 81.5 ± 1.5%) at the concentration of 3 mg/mL, with the IC₅₀value of 1.8 mg/mL. Furthermore, the ethanol extract of<em> C. indica</em> therapy at a dose of 100 mg/kg p.o significantly ameliorated the cognitive impaired mice in Y-maze task. The active ingredient was identified as 3,3’,4’,5,7-pentahydroxyflavone. The above results suggest that <em>C. indica</em> would be a potential natural therapeutic remedy for cognitive disorders mediated by cholinergic dysfunction.</p><p class="Abstract"><strong>Video Clip:</strong></p><p class="Abstract"><a href="https://youtube.com/v/QIEuwPT-lmw">Memory impairment test in mice</a>: 1 min</p><p> </p>

In the present study, we studied the effects of the ethanol extract of Commiphora berryi bark on drug-induced learning and memory-impaired mice using Y-maze task and passive avoidance task. On pretreatment with the ethanol extract of Commiphora berryi at 100mg/Kg p.o significantly ameliorated scopolamine-induced cognitive impairments which were revealed by the reversal in the reduction of spontaneous alteration in the Y -maze task and by significant improvement in latency time in passive avoidance task. This confirms the presence of bioactive phytoconstituents in Commiphora berryi which could be useful to decline the cognitive deficits in memory-impaired mice.