Gong (2019) Codelivery of DOX and siRNA by folate-biotinquaternized starch nanoparticles for promoting synergistic suppression of human lung cancer cells,

No abstract

In this paper, the β-cyclodextrin (β-CD) and biotin (Bi) were successfully grafted onto carboxymethyl chitosan (CMCS). And then the β-CD-Bi-CMCS nanoparticles (NPs) were prepared as oral nano-delivery carrier of protein drugs by ionic gelation method. The morphological feature of fabricated drug carrier was determined by dynamic light scattering and transmission electron microscopy. The result showed that the prepared NPs presented spherical structure with an average diameter of 138 nm. Bovine serum albumin (BSA) was selected as model protein drug that was entrapped in prepared drug carrier with satisfactory entrapment efficiency (79.18%) and loading content (3.96%). The drug release profiles of BSA/β-CD-Bi-CMCS NPs were studied at different pH environment for simulated gastric fluid (SGF), simulated intestinal fluid (SIF) and simulated colonic fluid (SCF). It was found that the BSA/β-CD-Bi-CMCS NPs displayed a pH dependent drug release profiles. After 72 h, the cumulative release amount of BSA in SGF, SIF, and SCF was about 20.57, 74.46, and 91%, respectively. Furthermore, the enzymatic degradation and cytotoxicity studies showed the synthesized β-CD-Bi-CMCS NPs had high chemical stability and biocompatibility. This work indicated that the β-CD-Bi-CMCS NPs had the potentiality as promising nanocarriers for oral delivery of protein drugs.

No abstract

Bisphenol A (short as BPA) is usually used for thermochromic products, and in recent years, it begins to be applied in functional textile with thermochromic performance. As a kind of environmental hormone, BPA is generally considered as chemicals with risks for its embryo toxicity and teratogenicity, which can result in cancer. In this study, thermochromic textiles in current market are collected for samples as many as 12 pieces. Experiments have been done for the determination of BPA in these samples to work out the health risks of thermochromic textiles. The results request laws or regulations on content of BPA in functional textile, because the HPLC-FLD/DAD test results showed detection of BPA in all samples, and some of which even have a high BPA content which will lead high risk to consumers and environment