The present investigation is aimed to formulate & characterize the immediate release tablet of Efavirenz by using Soluplus as a polymer. The proposed formulation of the immediate release tablet of Efavirenz are prepared by using solid dispersion by hot melt technique to improve solubility and dissolution rate of poorly water soluble Efavirenz. The drug to polymer ratio in optimized batch (TABSD13) was 1:3. The obtained batch was characterized for its percent drug contenet, thermal analysis (DSC), crystallinity (PXRD), FTIR and in vitro drug release. There were no compatibility issues and the crystallinity of drug was found to be reduced in prepared tablet which were confirmed by DSC and PXRD studies. The average dissolution rate of six Efavirenz tablet & marketed formulation in 0.5 % SLS in distilled water in 45 min were 72.77 % & 69.37 % respectively while in 120 min they were about 90.08 % & 88.24 % respectively & the standard deviations were also within the limits. It shows that the dissolution profiles of hot melt Efavirenz tablet & Marketed formulation were comparable in 0.5 % SLS in distilled water. This may be because of the SLS which act as good surfactant. Further investigations are required to reduce the amount of polymer in tablet that can provide maximum drug loading and acceptable dosage form.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.