No abstract

Herein, we report an efficient synthesis of N-substituted pyrrole derivatives and their application to construct macrocyclic oxazocinone via a two-component coupling reaction followed by base mediated intramolecular cyclization. This methodology provides an easy two-step approach to constitute a library of fused pyrrolo-oxazocinone derivatives in good yields under mild reaction conditions. The present methodology offers an easy access to the synthesis of a library of fluorescent pyrole derivatives. Among them, tert-butyl 2-(2-(3-hydroxypropyl)-7-methoxy-4,5-dihydro-2H-benzo[e]isoindol-1-yl)acetate has been employed in bio-analytical imaging which shows efficient cellular internalization along with no obvious cellular toxicity.

Herein, we report a rare pentacyclic N‐fused hetrocycle synthesis via palladium catalyzed intramolecular C−H arylation along with the brief synthetic study of new type of bicyclic/tricyclic pyrrole rings. This pyrrole rings provided diversely substituted polycyclic nitrogen fused heterocycles from N‐benzyl/N‐benzyloxy pyrroles with good to excellent yields.

We have reported a one-pot two step methodology for the synthesis of highly condensed pyrrolo[1,2-a][1,4]benzodiazepines by modified Pictet–Spengler reaction.

A short, efficient and general methodology for benzo [b]carbazolenaphthoquinones was developed via Pdcatalyzed C-H arylation process. This methodology was successfully applied to the synthesis of highly biologically active compound 5H-benzo[b]carbazole-6,11-diones. Additionally, one-pot synthesis of benzo[b] phenazine-6,11(5H,12H)-dione derivatives was also explored in aqueous medium.