No abstract

The preparation of a polymer-supported ruthenium alkylidene metathesis catalyst is described. This immobilized catalyst has been used to initiate a ring-opening metathesis polymerization of norbornene derivatives onto a polymer support to prepare novel high-loading resins for use in combinatorial chemistry.

The synthesis and use of two novel high-loading Horner−Emmons ring-opening metathesis polymers are described. α,β-Unsaturated ethyl esters (E:Z > 99:1) and α,β-unsaturated nitriles (E:Z > 70:30) are obtained in excellent yields and purities from aldehydes with minimal purification.

[figure: see text] The synthesis of ring opening metathesis, polymer-supported Tosmic reagent 1 is described. This reagent was utilized in the conversion of aldehydes to oxazoles in good yields and purities.

[reaction: see text] A novel N-hydroxysuccinimide ring-opening metathesis polymer is described as a recyclable supported acyl transfer reagent. Amides, carbamates, ureas, Weinreb amides, and hydroxamic acids are all obtained in excellent yields and purities from amines with minimal purification.