Competition to ensure sustainable conditions for graduates’ knowledge, skills, and competencies (KSC) and employability for sustainable development of human resources has long been present in higher education institutions (HEIs). The purpose of this study is to examine the roles of educational processes, practical activities, and research activities as key determinants to predict KSC and employability in the context of medical education in Indonesian HEIs. Moreover, this study also reports the role of facilities in predicting educational processes, practical activities, and research activities. This survey study obtained data from 1086 respondents, who are students of two medical schools. The data were analyzed by assessing the measurement and structural model in the partial least square structural equation model (PLS-SEM). Overall, all hypotheses were supported; the strongest relationship emerged between facilities and research activities, while the lowest relationship was present between practical activities and employability. From a theoretical perspective, the findings offer a conceptual framework related to HEIs’ quality management factors. Highlighting the significant relationships, appropriate policies can be produced for more quality institutions in improving graduates’ KSC and employability for the labor market.

Dengue fever is a disease spread by mosquito's bite. Dengue fever is marked by the presence of thrombocytopenia. Traditional crops such as guava are commonly used to treat dengue fever. This research aims to know the effect of guava extract administration towards megakaryocytes amount in mice femur. The study was conducted at the Laboratory of Pharmacology and Therapy, Histology Laboratory of Faculty of Medicine at Universitas Padjadjaran, Eijkman, Bandung from September until November 2016 using laboratory experimental study design. 20 Swiss webster mice strains were divided randomly into 4 groups. Group I and II were administered quinine 2.8 mg/20 grBW/day for 14 days to decrease amount of trombocytes. Group II and III were administered guava extract 0.785 mg/20 grBW/day for 5 days. Group IV was administered aquadest for 19 days. In the 27 th day, the mice left femurs were collected and made into paraffin section preparations with hematoxylin-eosin staining and then observed under microscope. Group IV had the most megakaryocytes followed by Group II, III, and I. Based on Kruskal-Wallis test, a significant difference was shown (p<0.05). MannWhitney test showed that there were significant differences between Group I and Group II, III, and IV. Meanwhile there was no significant difference between normal mice and extract-given mice. Guava extract is proven statistically significant to increase the megakaryocytes amount in thrombocytopenic mice without increasing number of megakaryocytes in normal mice.

Background Preeclampsia is a complication during pregnancy characterised by new-onset hypertension and proteinuria that develops after 20 weeks of gestation. Dyslipidemia in pregnancy is correlated with an increased risk of preeclampsia. However, the dynamic changes in lipid metabolic product, particularly fatty acid fraction, in preeclampsia maternal circulation, are not well understood. This study aimed to investigate fatty acid fraction in preeclampsia maternal blood compared with normotensive normal pregnancy. Methods A total of 34 women who developed preeclampsia and 32 women with normotensive normal pregnancy were included in our case-control study. Maternal blood samples were collected for serum fatty acid fractions analysis and other biochemical parameters. Serum fatty acid fractions included long-chain polyunsaturated fatty acid (LCPUFA), monounsaturated fatty acid (MUFA), saturated fatty acid, and total fatty acid, measured with gas chromatography-mass spectrometry (GC-MS). The mean difference of fatty acid level was analysed using parametric and non-parametric bivariate analysis based on normality distributed data, while the risk of preeclampsia based on fatty acid fraction was analysed using a logistic regression model. Results Women with preeclampsia have lower high-density lipoprotein (53.97 ± 12.82 mg/dL vs. 63.71 ± 15.20 mg/dL, p = 0.006), higher triglyceride (284.91 ± 97.68 mg/dL vs. 232.84 ± 73.69 mg/dL, p = 0.018) than that in the normotensive group. Higher palmitoleic acid was found in women with preeclampsia compared to normotensive normal pregnancy (422.94 ± 195.99 vs. 325.71 ± 111.03 μmol/L, p = 0.037). The binary logistic regression model showed that pregnant women who had total omega-3 levels within the reference values had a higher risk of suffering preeclampsia than those with the higher reference value (odds ratio OR (95% CI): 8,5 (1.51–48.07), p = 0.015). Pregnant women who have saturated fatty acid within reference values had a lower risk for suffering preeclampsia than those in upper reference value (OR (95% CI): 0.21 (0.52–0.88), p = 0.032). Conclusion Overall, palmitoleic acid was higher in women with preeclampsia. Further analysis indicated that reference omega-3 in and high saturated fatty acid serum levels are characteristics of women with preeclampsia.

Objective: The purpose of this study was to determine the mechanism through which guava extract increases platelet count. Methods:Twenty male Swiss webster mice were divided into 4 group. Group I received 2.8 mg/20 g body weight of quinine and 1 ml of distilled water. Group II received 2.8 mg/20 grBW of quinine and 0.785 mg/20 grBW of guava extract. Group III received 1 ml distilled water and 0.785 mg/20 grBW of guava extract and Group IV only received 1 ml distilled water. After 14 days** treatment, platelet count was measured using RaasEcker method. SCF and TPO mRNA expressions in mice liver were assessed using qRT-PCR. Results:The data showed that quinine administration reduced platelet count significantly (P<0.05). Psidium guajava L. extraction significantly enhanced platelet count in mice that were treated with quinine compared with quinine group (p<0.05). The mechanism was analysed further and our RT PCR data showed that stem cell factor mRNA expression significant increased (p<0.05) in quinine plus guava extract group compared to quinine group. Conclusion:It indicated guava extract role in increasing megakaryopoiesis which resulted in an increase of platelet count.

Current medical education curriculum refers to the Indonesian Medical Doctor’s Standard of Competence 2012. Competencies are detailed in seven general areas of competence to be achieved by medical students. This study focused on the development of learning media in the form of guide book and video related to the basic obstetric ultrasound examination and its influence in improving student’s knowledge of basic obstetric examination skills. A quantitative method used to see the effectiveness of the learning media that we developed. Twenty-one under graduate medical students who undertook clinical rotation in the Department of Obstetrics and Gynecology participated in this study through completing the pre-post student’s questionnaires to assess the students' knowledge before and after the delivery of learning media. The collected data were analyzed with a computer program; Means and Standard Deviation were calculated as descriptive parameters. Parametric tests were used to test the hypotheses. The pre-post results were compared using the Wilcoxon statistical test. The results showed a significant difference in the score of pretest and posttest. There was an increase in the average score of pretest and posttest for students after obtaining the teaching media and clinical supervision. The value of each individual was also increased. The analysis with the Wilcoxon statistical test showed significant differences which mean that there were improvements on student’s knowledge of basic obstetric examination skills after the delivery of guide book and video. The use of teaching media in the form of basic obstetric ultrasound module and video contributed to positive results to improve the student’s knowledge.