Competition to ensure sustainable conditions for graduates’ knowledge, skills, and competencies (KSC) and employability for sustainable development of human resources has long been present in higher education institutions (HEIs). The purpose of this study is to examine the roles of educational processes, practical activities, and research activities as key determinants to predict KSC and employability in the context of medical education in Indonesian HEIs. Moreover, this study also reports the role of facilities in predicting educational processes, practical activities, and research activities. This survey study obtained data from 1086 respondents, who are students of two medical schools. The data were analyzed by assessing the measurement and structural model in the partial least square structural equation model (PLS-SEM). Overall, all hypotheses were supported; the strongest relationship emerged between facilities and research activities, while the lowest relationship was present between practical activities and employability. From a theoretical perspective, the findings offer a conceptual framework related to HEIs’ quality management factors. Highlighting the significant relationships, appropriate policies can be produced for more quality institutions in improving graduates’ KSC and employability for the labor market.

Background Preeclampsia is a complication during pregnancy characterised by new-onset hypertension and proteinuria that develops after 20 weeks of gestation. Dyslipidemia in pregnancy is correlated with an increased risk of preeclampsia. However, the dynamic changes in lipid metabolic product, particularly fatty acid fraction, in preeclampsia maternal circulation, are not well understood. This study aimed to investigate fatty acid fraction in preeclampsia maternal blood compared with normotensive normal pregnancy. Methods A total of 34 women who developed preeclampsia and 32 women with normotensive normal pregnancy were included in our case-control study. Maternal blood samples were collected for serum fatty acid fractions analysis and other biochemical parameters. Serum fatty acid fractions included long-chain polyunsaturated fatty acid (LCPUFA), monounsaturated fatty acid (MUFA), saturated fatty acid, and total fatty acid, measured with gas chromatography-mass spectrometry (GC-MS). The mean difference of fatty acid level was analysed using parametric and non-parametric bivariate analysis based on normality distributed data, while the risk of preeclampsia based on fatty acid fraction was analysed using a logistic regression model. Results Women with preeclampsia have lower high-density lipoprotein (53.97 ± 12.82 mg/dL vs. 63.71 ± 15.20 mg/dL, p = 0.006), higher triglyceride (284.91 ± 97.68 mg/dL vs. 232.84 ± 73.69 mg/dL, p = 0.018) than that in the normotensive group. Higher palmitoleic acid was found in women with preeclampsia compared to normotensive normal pregnancy (422.94 ± 195.99 vs. 325.71 ± 111.03 μmol/L, p = 0.037). The binary logistic regression model showed that pregnant women who had total omega-3 levels within the reference values had a higher risk of suffering preeclampsia than those with the higher reference value (odds ratio OR (95% CI): 8,5 (1.51–48.07), p = 0.015). Pregnant women who have saturated fatty acid within reference values had a lower risk for suffering preeclampsia than those in upper reference value (OR (95% CI): 0.21 (0.52–0.88), p = 0.032). Conclusion Overall, palmitoleic acid was higher in women with preeclampsia. Further analysis indicated that reference omega-3 in and high saturated fatty acid serum levels are characteristics of women with preeclampsia.

Current medical education curriculum refers to the Indonesian Medical Doctor’s Standard of Competence 2012. Competencies are detailed in seven general areas of competence to be achieved by medical students. This study focused on the development of learning media in the form of guide book and video related to the basic obstetric ultrasound examination and its influence in improving student’s knowledge of basic obstetric examination skills. A quantitative method used to see the effectiveness of the learning media that we developed. Twenty-one under graduate medical students who undertook clinical rotation in the Department of Obstetrics and Gynecology participated in this study through completing the pre-post student’s questionnaires to assess the students' knowledge before and after the delivery of learning media. The collected data were analyzed with a computer program; Means and Standard Deviation were calculated as descriptive parameters. Parametric tests were used to test the hypotheses. The pre-post results were compared using the Wilcoxon statistical test. The results showed a significant difference in the score of pretest and posttest. There was an increase in the average score of pretest and posttest for students after obtaining the teaching media and clinical supervision. The value of each individual was also increased. The analysis with the Wilcoxon statistical test showed significant differences which mean that there were improvements on student’s knowledge of basic obstetric examination skills after the delivery of guide book and video. The use of teaching media in the form of basic obstetric ultrasound module and video contributed to positive results to improve the student’s knowledge.

BACKGROUND: Diabetic nephropathy (DN) is a chronic kidney disease with microvascular complications which influence a patient’s quality of life and poses a potentially significant economic burden. The discovery of new biomarkers is needed to gain a better understanding and find additional treatment approaches beyond controlling plasma glucose and blood pressure. The engulfment and cell motility protein called engulfment and cell motility protein (ELMO)-1 is known to play a role in tissue remodeling and is associated with DN progression in animal models. Human studies correlating this protein with DN have been limited, although a genetic variation of ELMO-1 has been associated with DN. AIMS: This research aimed to investigate the association and correlation of circulating ELMO-1 with the level of kidney damage in DN. METHODS: The research design was cross-sectional. In this study, 60 patients with type 2 diabetes mellitus (T2DM) participated. Patients’ blood pressure, plasma glucose, and renal function parameters were measured to confirm the diagnosis. Albumin to creatinine ratio (ACR) was used to assess the level of kidney damage and determines DN group. RESULTS: Analyses shown the severity of albuminuria which is associated with plasma ELMO-1 when DN is evident. Furthermore, in all study participants, plasma ELMO-1 was correlated with increased proteinuria, ACR, and decline of glomerular filtration rate. CONCLUSIONS: Our research findings provide support for ELMO-1 as a promising marker of kidney damage level in patients with T2DM, especially when DN has occurred. Larger sample sizes and multicenter research in the Indonesian population are needed to confirm these results.

Objective Calcitonin receptor-like receptor (CRLR) regulates vasoconstriction and dilatation; the expression increases during hypoxia via activation of hypoxia response element (HRE) in CRLR gene promoter region. Variant in HRE, as well short tandem repeat (STR) variants near HRE in CRLR alters the gene expression. This study focused on a case–control study to investigate the expression of genetic typing CLRL promoter variant in pregnant women with severe preeclampsia and normal pregnancies, we also tried to describe interesting findings of the genetic expression in anemic patients in the severe preeclampsia group. Our aimed to observe the correlation of CRLR gene promoter variant and anemia in severe preeclampsia. Results There was no nucleotide variant in HRE; CACA box prior to HRE varied in length (15–24); CACA box with length > 20 was used as cut off point. Hb was lower in CACA box length ≥ 21 (10.33 ± 1.57) vs. < 21 (11.01 ± 1.67; p = 0.391). CACA box polymorphism and anemia were correlated in severe preeclampsia (p = 0.005) OR 0.038 (CI 0.003–0.544); not in normal (p = 0.069).