Plasma Levels of the Engulfment and Cell Motility Protein-1 are Associated with Kidney Damage in Diabetic Nephropathy: A Single-Center Pilot Study in Indonesia Population

Abstract

BACKGROUND: Diabetic nephropathy (DN) is a chronic kidney disease with microvascular complications which influence a patient’s quality of life and poses a potentially significant economic burden. The discovery of new biomarkers is needed to gain a better understanding and find additional treatment approaches beyond controlling plasma glucose and blood pressure. The engulfment and cell motility protein called engulfment and cell motility protein (ELMO)-1 is known to play a role in tissue remodeling and is associated with DN progression in animal models. Human studies correlating this protein with DN have been limited, although a genetic variation of ELMO-1 has been associated with DN.
 AIMS: This research aimed to investigate the association and correlation of circulating ELMO-1 with the level of kidney damage in DN.
 METHODS: The research design was cross-sectional. In this study, 60 patients with type 2 diabetes mellitus (T2DM) participated. Patients’ blood pressure, plasma glucose, and renal function parameters were measured to confirm the diagnosis. Albumin to creatinine ratio (ACR) was used to assess the level of kidney damage and determines DN group.
 RESULTS: Analyses shown the severity of albuminuria which is associated with plasma ELMO-1 when DN is evident. Furthermore, in all study participants, plasma ELMO-1 was correlated with increased proteinuria, ACR, and decline of glomerular filtration rate.
 CONCLUSIONS: Our research findings provide support for ELMO-1 as a promising marker of kidney damage level in patients with T2DM, especially when DN has occurred. Larger sample sizes and multicenter research in the Indonesian population are needed to confirm these results.

The Role of Angiotensinogen rs699 in Diabetic Nephropathy Among Type 2 Diabetes Mellitus Patients with Uncontrolled Postprandial Glucose Levels

“…The urine ACR in this study was calculated using random spot urine sampling. It is because a previous study reported that this sampling was more representative and practical in assessing albuminuria associated with complications of diabetes mellitus than a 24-hour urine sample (Elfiani et al, 2020). Albuminuria in patients with diabetes mellitus provides an early indication of kidney damage (Seidu, Barrat and Khunti, 2020).…”

“…However, previous studies found that uncontrolled blood glucose levels or hyperglycemia were not significantly correlated with an increased risk of DN in individuals with T2DM https://doi.org/10. 33086/jhs.v15.i03.2681 Devy Afriyanti -The Role of Angiotensinogen rs699 in Diabetic Nephropathy Among Type 2 Diabetes Mellitus Patients with Uncontrolled Postprandial Glucose Levels (Elfiani et al, 2020). It certainly indicates the possibility of other risk factors more involved in developing DN, one of which is genetic factors.…”

Genetic variant of TGF-ß associated with decreased renal function in type II diabetes mellitus patient: single center pilot study in Indonesia

“…5 The study in Malay Jambi ethnic reported similar result. 6 The new biomarker and genetic variant may play role in this event. Genetic factors are risk factors that cannot be modified, but early screening of these factors can provide information about the pathophysiology of DKD and promises hope for better treatment and prognosis.…”