The occurrence of a neoplasm of a cell type different from that found in the normal organ is always of considerable interest. Eighty‐five cases of either pure squamous cell carcinoma or adenosquamous cell carcinoma of the stomach have been reported to date with an incidence calculated in different series between 0.04 and 0.7%. Its sex ratio is 4:1 in favor of men. The theories of the pathogenesis of such tumors with unexpected cell types have been reviewed. To the authors, prior squamous cell metaplasia of the gastric mucosa seems essential for the pathogenesis of the pure type of this unusual neoplasm, but, in the mixed tumor, either squamous differentiation in an adenocarcinoma or in a cell capable of differentiating along both cell types appears more likely. An additional case of the mixed type is added to the literature.

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