In this study, we propose a multifunctional weak measurement system that can measure the optical rotation and the refractive index of solution. The center wavelength of the output spectrum of such a system is sensitive to the optical rotation and the phase difference produced by total internal reflection. The optical resolution and refractive index resolution of the solution determined by the proposed method were 3.26 × 10–5° and 3.93 × 10–7 RIU, respectively, by measuring different concentrations of glucose solution. As the optical rotation and refractive index of the solution are important properties of the solution, this system can be used to determine the type of solute in the solution in the future.
In the field of electrochemical energy storage systems, the use of in situ detection technology helps to study the mechanism of electrochemical reaction. Our group has previously in situ detected the electrochemical reaction in vanadium flow batteries by total internal reflection (TIR) imaging. In order to further improve the detection resolution, in this study, the weak measurement (WM) method was introduced to in situ detect the electrochemical reaction during the linear sweep voltammetry or the cyclic voltammetry tests with quantitative measurement of the absolute current density, which lays a foundation for replacing the TIR for two-dimensional imaging of electrochemical reactions in vanadium flow batteries, oxygen/hydrogen evolution reaction, surface treatments, electrochemical corrosion and so on.
In this paper, we propose a linear differential detection system based on a frequency domain weak measurement. The system can be used for detecting optical substances. Moreover, we completed an experiment to detect himan serum albumin (HSA) content in a mixture of human serum albumin and L-proline via dialysis. This work also proves the differential function of the system. This experiment can be further extended to detecting protein content in a mixed solution that contains protein macromolecules and various small molecules. It is very important for detecting molecules without photomarking in solutions of complex biological samples. In this paper, the system has an optical resolution of 1.39 × 10 −5 , and resolution of 4.06 × 10 −8 mol/L for himan serum protein solution.
Diabetes is an important public health problem and finding quick testing methods with high accuracy, reliability, and convenience are important to control the blood glucose of diabetic patients. In this study, a sensor based on a weak measurement scheme was developed for the specific detection of glucose for the first time. The detection of glucose using the proposed method was completed by the high sensitivity and resolution of the weak measurement based on optical rotation detection, as well as the change in the optical rotation before and after the specific oxidation of glucose. The resolution of the as-obtained glucose sensor was around 2.71×10−3 g/L (1.50×10−2 mmol/L), and the detection range was 0–11 g/L (0–61 mmol/L).
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