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unsuccessful. Only single inflections were observed. This indicates the differences in the magnitude of maximum AE/AV probably represent minor differences in actual base strength. DISCUSSIONSulfides and sulfones, possible impurities in sulfoxides, in general exhibit no measurable basicity in acetic anhydride when titrated with perchloric acid.Trimethylphosphine oxide, though not a sulfoxide, has been included for comparison as amine oxides have been found to exhibit very sharp inflections in acetic anhydride. Diethoxy sulfoxide (diethyl sulfite) could not be titrated as a base in acetic anhydride.The direct titration of sulfoxides in acetic anhydride offers a rapid and reproducible approach to purity determination. The method appears to be limited only by the solubility of the particular sulfoxide in acetic anhydride.