No abstract

No abstract

Chloroform has been one of the most commonly used anaesthetics for almost a century. I n the last fifty years, however, its use has been greatly restricted because of serious side-effects. These may be immediate (cardiac arrhythmia) o r late (degenerative changes in certain organs, particularly the liver). Nowadays, the use of chloroform anaesthesia is almost restricted to obstetric practice and it is then only used in small doses towards the end of the second stage of labour. In Sweden chloroform anzsthesia is rarely used outside the teaching hospitals (af G e i j e r s t a m and L i n d g r e n , 1960).I n experiments on mice, P l a a ef al. (1958) determined the relative hepatotoxicity of chloroform and carbon tetrachloride injected subcutaneously and reported that the effective dose (ED,,) of chloroform was about three times greater than that of carbon tetrachloride. M y r e n (1956) observed histological changes in the liver cells of mice following subcutaneous injection

No abstract

No abstract