Introduction. Pathological changes in the periodontium in people with diabetes mellitus, according to some data, are aggravated after orthodontic intervention, which dictates the need to carry out preventive measures, the effectiveness of which will determine the quality of orthodontic treatment. The aim of this study was to study the periodontal protective effect of two domestic antidisbiotic drugs containing plant extracts, vitamins, calcium and phosphorus salts. Methodology. The experiments were carried out on white Wistar rats, divided into 5 groups. The gums and periodontal bone tissue were isolated. The activity of urease, lysozyme and the content of hyaluronic acid was determined in the gingival homogenate, and the degree of dysbiosis was calculated. In the homogenate of the periodontal bone tissue, the activity of alkaline and acid phosphatases was determined, the mineralization index and the degree of mineralization, as well as the content of calcium and protein, were calculated. Results. The obtained results of our study have convincingly proved the pronounced periodontal protection efficacy of antidisbiotic drugs for oral applications of the plates "CM-2" and the drug Enoant polyphenols. The proposed therapeutic and prophylactic complex inhibits inflammation, destruction of bone tissue and the development of dysbiosis, along with the manifestation of pronounced adaptogenic, antimicrobial and periodontal protective effects in experimental animals against the background of the development of type 2 diabetes mellitus and orthodontic tooth movement. Conclusion. The proposed therapeutic and prophylactic complex inhibits inflammation, destruction of bone tissue and the development of dysbiosis in experimental animals against the background of the development of type 2 diabetes mellitus and orthodontic tooth movement. The obtained results of the experimental study serve as the basis for the recommendation of the investigated complex, including the local application of plates with herbal extracts, vitamins, calcium and microelements, along with the systemic use of grape polyphenol concentrate, in an orthodontic clinic for patients with diabetes mellitus.

1 медицинская академия им. С. И. Георгиевского Крымского федерального университета им. В. И. Вернадского, Симферополь, Российская Федерация 2 Институт стоматологии и челюстно-лицевой хирургии Национальной академии медицинских наук, Одесса, Украина effecT of anTidisBioTic drugs on periodonTal Tissues of raTs WiTh diaBeTes melliTus afTer orThodonTic TooTh relocaTion demyanenko s. a. 1 , morozov a. l. 1 , morozova m. n. 1 , shabliy d. n. 1 , denga a. e. 2 1 medical academy named after s. i. georgievsky of V. i. Vernadsky crimean federal university, simferopol, russian federation 2 The institute of dentistry and maxilla-facial surgery, national academy of medical sciences, odessa, ukraine Целью данного исследования стало определение влияния ортодонтического перемещения зубов на состояние пародонта у крыс с экспериментальным сахарным диабетом и определение возможности предотвращения патологических изменений с помощью антидисбиотических средств. В опытах на белых крысах линии Вистар выделяли десну, костную ткань пародонта, а также получали сыворотку крови. В гомогенате десны определяли уровень биохимических маркеров воспаления, а в гомогенате костной ткани пародонта определяли активность щелочной и кислой фосфатаз, активность эластазы, а также содержание кальция и белка. Результаты исследований свидетельствуют о развитии системного воспаления, активации перекисного окисления липидов, воспаления и об усилении контаминации на деснах условно-патогенной микробиоты, развитии дисбиоза на фоне снижения антимикробной защиты в полости рта. Результаты дают основание рекомендовать применение исследованных антидисбиотических средств перед ортодонтическим перемещением зубов у пациентов с сахарным диабетом.

The study demonstrated the effectiveness of nanosilver (linear particle size 10-20 nm) in the form of a patented composition. This form showed high bactericidal and fungicidal activity against gram-positive, gram-negative bacteria and candida in minimal concentrations.

The purpose of the research: to study the hygienic condition of the oral cavity and clinical manifestations of diseases of the oral mucosa in patients with COVID-19 in a hospital setting and to justify the need to motivate early hygienic measures using a toothbrush and toothpaste in this contingent of patients. Material and methods. We observed 43 patients of the infectious diseases department of the Simferopol clinic aged 21–25 years with COVID-19 of mild and moderate severity. All patients underwent a comprehensive dental examination with the determination of the Green–Vermillion index, the PMA index. Particular attention was paid to the hygiene products used and the regime of hygienic measures before and during hospital stay. Results and their discussion. It was found that 67.44% of the surveyed brushed their teeth with different frequency of use of a toothbrush and toothpaste. Before admission to the hospital, 93.02% of patients brushed their teeth regularly 2 times a day. 27.91% used cleaning tampons and a mouthwash, 4.65% of the surveyed did not brush their teeth. A significant increase in the hygiene index and the PMA index was revealed in patients of groups 1 and 2 who do not use a toothbrush and paste for oral care (p < 0.001). In 27.91% of patients, changes in the lips and oral mucosa was noted: 4.65% – recurrent labial herpes, 4.65% – desquamative glossitis, aphthous rashes – 16.28%, lichenoid manifestations – 2.32% of the examined. Healing of aphthous lesions of oral mucosa in patients who brushed their teeth was noted on the day 5–10, and in patients who did not brush their teeth – on 15th day. Conclusions. The data obtained in our research indicate the need for active motivation of patients with COVID-19 in a hospital setting for early hygienic measures with the mandatory use of a toothbrush and toothpaste.

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