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Poster Session 2Efficacy of satralizumab as monotherapy in pre-specified subgroups of SAkuraStar, a double-blind placebo-controlled phase 3 clinical study in patients with neuromyelitis optica spectrum disorder (NMOSD)

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The aim: is to evaluate peculiarities of clinical and neurological characteristics, quality of life, brain morphometry changes and metabolic deviations of patients, who suffered from aneurysmal subarachnoid hemorrhage. Materials and methods: In the period of 2016-2019 we examined 114 patients, who signed the informed consent, taking into account their age, clinical and anatomical form of hemorrhage, disease duration, Hunt-Hess severity grade, complications of acute period. Such parameters were evaluated, as clinical and neurological characteristics, the degree of the Barthel index and the modified Rankin scale, cognitive functioning (MoCA), psycho-emotional sphere and quality of life (HADS, SF-36), morphometric parameters based on brain computed tomography measurements, explored the indicators of apoptosis, mitochondrial dysfunction, intracellular oxidative stress. Results: Сephalgia (90,35 %), pyramidal syndrome (53,50 %), sensibility deficit (36,84 %) were leading among the all neurological syndromes. Slight dependence and disability grade was found during assessment of the Barthel index and the modified Rankin scale. In 85,96 % of patiens we revealed cognitive impairment of different severity grades. The anxiety was manifested in 65,79 %, depression – in 64,91 % of patients. Due to the morphometry data, the process of cerebral atrophy was detected (central – in 26,31 % of patients, cortical – in 16,67% and mixed – in 28,07 %). AnV+ and PI+ – cells level exceeded normal values in 2,88 and 1,96 times while the level of JC-1+ and ROS+-cells – in 2,17 and 2,82 times (p<0,01). Conclusions: Having studied clinical and neurological, neuropsychological, morphometric and metabolic factors, we found their pathogenetic role in the course of late recovery and residual periods of aneurysmal subarachnoid hemorrhage, that would help us to improve the diagnostic tactics and reveal the predictors of unfavorable outcome.

Objectives. The aim of the present study was to clarify clinical neurological characteristics and different ischemic stroke subtypes unfavorable course predictors in acute phase.Material and methods. 482 patients with different ischemic stroke subtypes were observed. Among them there were 125 (25.9 %) with cardioembolic infarct (CEI), 119 (24.7 %) with large artery atherosclerosis (LAAS) infarct, 122 (25.3 %) with lacunar stroke (LAC), 116 (24.1 %) with stroke of undetermined etiology (UDE). The comparative analysis of clinical picture was performed. The predictors of unfavorable course of acute phase were established.Results. We have found out that severe neurological deficit, high mortality and the worst functional outcome during the first 14 days were observed in patients with CEI and LAAS. The highest frequency of early neurological deterioration (END) was detected at LAC (in 22.7 % of patients). There was a relationship between END and presence of transient ischemic attack (TIA) in past medical history, the level of systolic blood pressure (SBP) at the beginning of the disease and the degree of carotid arteries stenosis on the side of lesion. The patients with LAC had mild neurological deficit and better prognosis compared with other ischemic stroke subtypes. Among the clinical factors that have impact on the CEI, LAAS and UDE acute phase course were: the size of lesion, the level of consciousness on the 1st day, the baseline SBP, patient's age. At LAAS, the presence of transient ischemic attack (TIA) in past medical history and low SBP in the onset of the disease (less than 140 mm Hg) has an additional prognostic value for an unfavorable functional outcome. The severity of LAC in acute period depended on its localization and size. Localization of LAC in the internal capsule, thalamus and pons were characterized by the highest severity. Conclusions.Clinical neurological features of ischemic stroke depend on its subtype and have some prognostic value for the course of different ischemic stroke subtypes in acute phase.Клініко-неврологічні особливості перебігу підтипів ішемічного інсульту в гострому періодіМета роботи -уточнити клініко-неврологічні особливості та предиктори несприятливого перебігу різних підтипів ішемічного інсульту в гострому періоді.Матеріали та методи. У 482 осіб із різними підтипами ішемічного інсульту (125 (25,9 %) з кардіоемболічним інсультом (КЕІ), 119 (24,7 %) -з атеротромботичним інсультом (АТІ), 122 (25,3 %) -з лакунарним інсультом (ЛІ) та у 116 (24,1 %) пацієнтів -з інсультом невизначеної етіології (ІНЕ) здійснили порівняльну характеристику особливостей клінічної симптоматики та визначили предиктори несприятливого перебігу гострого періоду.Результати. Встановили, що найтяжчий неврологічний дефіцит, найвища смертність і гірший функціональний резуль-тат протягом перших 14 днів захворювання спостерігались при КЕІ та АТІ. Найвища частота раннього неврологічного погіршання (РНП) виявлена при АТІ (у 22,7 % пацієнтів). Спостерігалась залежність між РНП із наявністю в анамнезі транзиторної ...