Soft tissue sarcomas are broad group of malignant tumours that arise in tissues like fat, muscle, nerves, fibrous tissue and blood vessels. A variety of non mesenchymal neoplasms like sarcomatoid carcinomas, melanomas and extranodal lymphomas may also mimic soft tissue sarcoma. Diffuse Large BCell Lymphoma is the most common type of Non HodgkinsLymphoma accounting for around 30-40% of cases.DLBCL involving skeletal muscle is extremely rare accounting approximately <1% of the cases with most of the cases reported in the lower extremity involving calf and thigh region.Here we report a case of DLBCL of the left thigh mass in 60 years old male which was initially thought to be a sarcoma based on clinical findings and imaging, but was later diagnosed to be DLBCL after surgical excision of the mass with the help of histopathology and immunohistochemistry.

To study the accuracy of intraoperative frozen section diagnosis in assessing margins in oral cancer resection. But reliability of frozen sections in predicting the ultimate final margin status is unknown. We compared frozen and permanent reads to identify risk factors for overall discrepancies between intraoperative and final margin status. To evaluate the role of frozen section diagnosis as a guide in resection of oral cancer lesions. Pathology reports of 284 surgical resections specimens between 2018 and 2020 were retrospectively reviewed. A total of 104 cases (470) margins) met inclusion criteria. The reports of frozen sections are compared with the results of histologic findings obtained by routine paraffin embedded Haematoxylin and Eosin method. The comparison of the section from margins i.e. anterior, posterior, medial, lateral and deep, altogether 470 margins from 104 patients showed concordance in 437 margins, i.e. 446 margins were negative in both frozen section and Paraffin method and 16 margins were positive in both frozen section and Paraffin method. 22 margins were positive in paraffin method. 18 margins were positive in frozen section. The eight margins showed disagreement in frozen section and paraffin embedded Haematoxylin and Eosin method. Individual frozen section reads are highly accurate. However, negative intraoperative margins do not guarantee margin-negative resections. The process of selecting representative margins for intraoperative analysis should be refined. The surgeon and the pathologist must understand the limitations of frozen sections.

Oral cancer ranks as the sixth most common malignancy worldwide, with Squamous Cell Carcinoma (SCC) being the predominant type observed in the head and neck region. Incidence and mortality rates of SCC have significantly increased over the past few decades. Smoking and tobacco chewing are the most common aetiological factors, predominantly affecting elderly males. Distant metastasis at the time of diagnosis is a rare occurrence, typically disseminating through blood vessels or lymphatics. The lungs are the most frequent site for distant metastasis, followed by bone, mediastinal nodes, and occasionally the liver. However, in our cases, we observed metastasis to uncommon sites, excluding the liver. Accurate diagnosis necessitates the correlation with clinical history, radiological, histopathological, and immunohistochemical findings. Despite employing various surgical and radiotherapeutic modalities, distant metastasis diminishes the chances of survival, successful treatment, and worsens the prognosis. This article presents four cases of oral SCC that exhibited metastasis to unusual sites. Two cases had a primary tumour in the left lateral border of the tongue, with distant metastasis to the breast and skin (chest wall), while the other two cases had a primary tumour in the left buccal mucosa and left mandibular region, with distant metastasis to the kidney and liver.

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