Background: Breast cancer is one of the most common malignancies found among women in India. Haematological parameters have been shown to predict severity, mortality and treatment follow-up in breast cancer patients. The aim of the study was to compare haematological parameters along with effect of chemotherapy and radiotherapy in different stages of breast cancer patients.Methods: Total 235 human subjects were taken in the study. Out of which 100 normal ages matched healthy subjects were considered as controls and 135 breast cancer patients subjects as cases which were further divided into their respective stages according to TNM classification.Results: Estimation of haematological parameters was done by Sysmex Automated Hematology Analyzer Kx-21. The statistical differences between cases and control were determined by using student independent sample t-test.Conclusions: We found hemoglobin level, polymorphs, lymphocytes, monocytes and RBC count were statistically reduce (p<0.05) while other parameters were non-significant as compared to control healthy subjects. We also found deranged haematological parameters in all four stages of breast cancer. The data also indicated that patients which were on combined therapies i.e. radio and chemo have more deranged and decreased levels of haematological parameters as compared to individual therapies.

Utility of C-reactive protein (CRP) latex agglutination test in meningitis was evaluated. Serum CRP test was positive in 100% cases of meningitic groups and 53% cases of "no meningitis (NM)" group. Cerebrospinal fluid (CSF) CRP test was positive in 100% cases of pyogenic meningitis, whereas it was negative in 95% cases of tuberculous meningitis and 100% cases of NM group. CSF CRP test showed 100% sensitivity and negative predictive values, 95-100% specificity and 94-100% positive predictive values for various inter-group differentiations. This study concluded that CSF CRP positive cases should be considered as pyogenic meningitis unless proved otherwise. Routine use of this simple, reliable and inexpensive test is recommended for rapid diagnosis and differential diagnosis f meningitis.

Background: World health organization has promoted modified partograph with action line, 4 hour to left of alert line. While others have used various action line 2, 3, or 4 hours to initiate and guide ‘‘active management’’ decisions. Objectives of the study were to evaluate outcome of labour in terms of caesarean section rate, augmentation of labour and fetal outcome in whom labour has been managed with 4-hour vs 2-hour action line on WHO modified partograph.Methods: This was a randomized, prospective, comparative study. Primigravida, 19-28 years, with single live foetus in vertex presentation without any medical and obstetrical complications, at term pregnancy have been included in the study. Results were compared between Group A, with 100 cases, in whom labour has been managed with WHO modified Partograph with 4-hour action line and Group B, with 100 cases, in whom labour has been managed with that of 2-hour action line.Results: The present study shows that more women in 2-hour arm crossed the action line, compared with the 4-hour arm, and therefore received more interventions to augment labour.  Rate of caesarean section is more in group B (11%) than in group A (9%) which is statistically nonsignificant.Conclusions: Neonatal outcome measured with APGAR score at 5 minute, has shown no significant difference in both groups. Therefore, partograph with 2-hour action line doesn’t show any superiority over that of 4-hour action line but to be associated with higher incidence of intervention. Further research is required in this field of active management.

Background: The prevalence of anemia in India is increasing day by day and covers almost one third population. Anemia during pregnancy leads many perinatal complications such as miscarriage, abortion and still birth. So, the aim of the study was to determine prevalence of anemia during pregnancy and its association with adverse perinatal outcomes in region of Madhya Pradesh.Methods: The study population consisted of 15-49 years women of reproductive age group from the state Madhya Pradesh, India, which were taken from the National Family Healthy Survey-4 (2015-16). Various perinatal outcomes along with age and residence was cross tabulated and frequencies were generated. The chi-square statistic was used to test the significance.Results: In severe anaemic women prevalence of miscarriage (74.0%) was statistically significantly higher (p<0.05) as comparison to other forms of anemia. Also, in the age group 25-29 years and rural population prevalence of miscarriage (40% and 55%) was highly significant (p<0.001) as comparison to other age group and urban population.Conclusions: The severity of anemia is directly proportional to poor and adverse perinatal outcomes in pregnancy.

INTRODUCTIONLegally induced abortions, called as medical termination of pregnancy, form a major bulk in every day practice of gynaecology. Medication abortion (also referred to as medical abortion) is the termination of pregnancy with use of medications alone rather than surgery. Mifepristone, 200mg in combination with misoprostol, 800mcg is more effective up to 49 days of gestation, rather than in late first trimester of pregnancy.1 It is however not always the method of choice because of the long-time consumed to complete the abortion, inconvenience due to prolonged bleeding per vagina (P/V) and the risk of excessive bleeding P/V makes it unsuitable for its use in areas where round the clock emergency services are not available. Therefore, the surgical method like vacuum aspiration, dilatation and evacuation still remains the procedure of choice for termination of pregnancy. Cervical ripening or softening is the determining step for success of surgical method of termination. Insufficiently dilated cervix may cause difficulty in evacuating the uterus, excessive hemorrhage ABSTRACT Background: Cervical ripening is a critical step for surgical method of termination of first trimester of pregnancy. Misoprostol, PGE1 analogue have promising role as cervical ripening agent. The present study aimed to compare the efficacy and side effects of oral, sublingual and vaginal misoprostol at dosage of 400mcg for cervical priming before surgical method of termination in first-trimester pregnancy. Methods: It was a prospective hospital based randamosied study. Total 150 patients at 6-12 weeks gestation requesting for medical termination of pregnancy were divided equally in to 3 groups. Every group was advised to have single dose of 400 mcg misoprostol either oral, sublingual or vaginal route respectively 4 hour before suction and evacuation. Results: The sublingual group had highly significant cervical dilatation (P<0.001) and the duration of suction and evacuation was less as compared to the vaginal and oral routes (p<0.000). However, the mean intraoperative blood loss was more in sublingual as compared to the vaginal and oral groups. Loose motions and nausea/vomiting were more with oral routes while blood loss was more in the vaginal route. Conclusions: Thus, it can be concluded from present study that sublingual route of misoprostol is more preferable than oral or vaginal route as pro-abortion cervical ripening agent.