Background: Breast cancer is the commonest cancer in women worldwide and represents a disease with wide spectrum particularly in terms of tumour histology, biology, prognosis and response to therapy. Breast cancer is characterized by cellular heterogeneity. Methods: The study was conducted in the Department of Pathology, GSVM Medical College, Kanpur and associated hospital of Kanpur from January 2018 to September 2019 on patients of breast carcinoma. These cases were selected from the outpatient and inpatient of LLR Hospital, Kanpur, India. In the present study, we had taken a total of 80 cases of invasive breast carcinoma as well as Histomorphology, Ki-67 immunostaining and it's a correlation with lymph node status and tumour grade were studied. Results: This study leads us to conclude that the peak incidence of invasive breast carcinoma was reported in the age group of 41 to 50 years (with mean age 47.32 year and the standard deviation was 11.63). In the present study, the most common histological type was invasive ductal carcinoma, not otherwise specified (NOS). In our study, 66.25% of cases had metastatic lymph nodes and half of them were having more than 4 metastatic lymph node. In the grade-II of Bloom Richardson Grading system, there were 40% cases and in grade-III there were 35% of cases and grade-I has shown 25% of cases. A significant association was found between the grade of the tumor and the lymph node positivity. Conclusion: The present study concluded a positive correlation between the grade of tumour and Ki-67 immunohistochemistry, which was used as a prognostic and predictive parameter.

Background: Encapsulated follicular variant of papillary carcinoma of the thyroid is a common thyroid gland cancer with a highly indolent behavior. Methods: A fifty-five-year-old female patient presented with chief complaints of swelling on left side of the front of neck swelling, mild pain and hoarseness of voice. At the time of initial presentation the mass has not been changing in size nor did the patient experience any compressing symptoms. Complete blood count and other biochemical parameters were within normal limits. Results: Histopathological examination of thyroid showed encapsulated well defined nodular tissue comprising of numerous microfollicles, which were lined by atypical cuboidal cells having large irregular nuclei, prominent nuclei, fine powdery chromatin and the moderate amount of cytoplasm, few cells an showing nuclear clearing and grooving. On the basis of histopathological findings we have made the diagnosis of this rare case. Conclusion: Due to it is rare occurrence and very closes mimicker of follicular adenoma and carcinoma, we are presenting this rare case.

BACKGROUNDOral cancer is the 11 th most common cancer in the world, and death due to this, ranks 6 th globally. India has the highest incidence of oral cancer globally and accounts for approximately 30-40% of all other cancers. Squamous cell carcinoma is the most commonly encountered malignancy of the oral cavity. The most important prognostic factor for patients diagnosed with oral squamous cell carcinoma (OSCC) is metastasis to cervical lymph nodes or distant organs. METHODSThis study was carried out among patients attending ENT OPD in LLR Hospital attached to G.S.V.M. Medical College, Kanpur. A detailed clinical history of present illness including relevant past history was recorded and a complete general examination was done. A total of 100 cases diagnosed in histopathology laboratory between July 2017 and August 2019 were included. Expression of E-cadherin was evaluated in normal oral mucosa, oral premalignant lesions and oral squamous cell carcinomas and was correlated with pathological grade. RESULTSThere was male preponderance with a male to female ratio of 4.5:1. Maximum cases of oral lesions were encountered in fourth and fifth decades of life. Majority of the cases were tobacco users (85%). CONCLUSIONSCorrelation of Squamous Cell Carcinoma cases with the expression of intensity of staining with E-Cadherin was found to be significant with p<0.05. There was significant variation of expression of E-cadherin with histopathological dysplasia of the oral precancerous lesions and the tumour differentiation of the oral cancers in comparison with normal oral mucosa. However, there was no correlation between degree of loss of expression of E-cadherin with the degree of dysplasia or the tumour differentiation of oral cancers. There was a variation in the expression of E-cadherin, but its value as a prognostic marker is questionable for which a longitudinal study with larger sample size is required to confirm this conclusion.

Background: Neuroblastoma is the neurogenic, extracranial solid tumor of infancy and children emerging anywhere along with the peripheral sympathetic nervous system. Methods: An eight months old boy presented with chief complaints of sub-cutaneous non-tender nodule on the flexor aspect of forearm, pain and fullness of abdomen, emesis, mild bone pain. Complete blood profile and other biochemical parameter were within normal limits. Results: Fine needle aspiration cytology revealed tumour cells having high nucleo-cytoplasmic ratio bare nuclei, which were round to oval in shape. Homer wright rosette arrangement was formed by tumor cells that were radially arranged in a circle. The neuropil, which was stained as eosinophilic material was seen in the center of rosette arrangement. Conclusions: Hence on the basis of age and rare cutaneous presentation along with cytological findings; clinical features and radiological findings we can provide a diagnosis of metastasis neuroblastoma.

Background: Filariasis is a chronic disabling parasitic disease. It is more prevalent in the coastal areas and river banks of India. Breast is a very uncommon site of the filarial lesion. Methods: We have reported a case of 45 years old female with chief complaints of painless increasing breast mass on the left outer quadrant. There was no history of fever, weight loss, and anorexia as nipple discharge. On palpation swelling was large, mobile, soft cystic and diffuse USG revealed a hypoechoic lesion on the outer quadrant of the left breast. The diagnosis was confirmed by fine needle aspiration cytology of the breast aspirate. Results: A 45 years old female patient presents with a painless increasing breast mass. FNAC was performed and findings were suggestive of parasitic cyst in breast microfilaria. Conclusions: Absence of microfilaria in peripheral blood does not rule out filariasis. Filarial Breast Nodule was rare and it often mimics a neoplastic breast lesion so, FNAC was a very effective diagnostic tool in the diagnosis of filarial breast lesion.