Introduction: Appropriate wound closure with appropriate suture material is of prime significance in surgery. Hence, we aim to assess the efficiency of ISO amyl 2-cyanoacrylate glue in closure of extraoral surgical wound when compared with other suture materials like polypropylene (prolene), nylon (ethilon) and silk (mersilk). Materials and Methods: We conducted a prospective clinical observational study in which 60 subjects were divided into two groups: suture group and cyanoacrylate group. They were compared for wound healing complications on days 1, 3, 7, 12, and at 1 month postoperatively with P < 0.05 as significant. Results: We observed that there was no statistically significant difference between the groups for the various parameters of the wound healing for the different time periods except that color acceptability and visibility were significantly superior in the cyanoacrylate group. Conclusion: Iso amyl 2-cyanoacrylate can be used successfully in the suture closure with excellent patient satisfaction and can be considered as an alternative to the routine suture materials.