No abstract

Non-Alcoholic Fatty Liver Disease (NAFLD) is a clinical condition defined by excessive fat accumulation in the liver in the form of triglycerides involving more than 5% of hepatocytes. The present study was carried out with an aim to evaluate the association of demographic features, liver enzymes, serum lipid profile and APOC3 gene variants (C-482T and T-455C). A case-control study was designed with 150 patients with NAFLD, and 180 healthy controls. The mutations were analyzed using PCR-RFLP approach, Case-control studies assessing the relationship between APOC3 rs2854116 C/C and rs 2854117 C/T gene polymorphism with non-alcoholic fatty liver disease. Statistically significant increased frequencies of CC+CT genotype [OR, 2.00; 95 percent C. I (1.18-3.40); P.0006] [OR, 2.00; 9.5 percent C.I (1.38-2.91); P value < 0.0002] and the C allele is seen in NAFLD patients compared to healthy controls. In conclusion, we found that the APOC3 gene and elevated triglyceride levels in -455C/C SNP is significantly associated with the risk of NAFLD, whereas the Apoc3-482C/T showed no association.

Hepatocellular carcinoma (HCC), the most common malignant liver tumor, is usually asymptomatic but rarely bleeds into the peritoneal cavity which can be a serious catastrophe. In this case report, we are presenting a case of ruptured HCC, who came to our emergency room with hepatic decompensation in the form of jaundice and progressive abdominal distention and on evaluation were found to have ruptured HCC and the classical findings associated with it were the signs of intraperitoneal bleed like Cullen's and Grey-Turner's sign which are classically mentioned in acute pancreatitis.

Now a days platelet rich plasma is the new approach to the tissue regeneration process along with it platelet rich plasma is found to be of valuable use in promoting healing in various periodontal, dental and oral surgical procedures. Platelet rich plasma is basically derived from the own blood of the patient, that is containing growth factors with in it, which promotes the healing process in periodontal or other dental procedures.