Background: Uterine fibroid (UF) is a common tumor of the female reproductive system. Though most of the women with fibroids are asymptomatic, approximately 30% of them can mention about some severe symptoms like abnormal uterine bleeding, pelvic pain, anemia, back pain, urinary frequency and even infertility etc. Generally, among the patients with uterine fibroids, prevalence of vitamin D deficiency is found. But, the impact of vitamin D on reduction of the sizes the uterine fibroids are still unknown. Aim of the study: The aim of this study was to assess the impact of vitamin D supplementation among the women with uterine fibroid in different age groups. Methods: This prospective observational study was conducted in the department of Radiology & Imaging, BSMMU, Dhaka, Bangladesh during the period from January 2020 to December 2020. In total 75 women with uterine fibroid were enrolled in this study as study population. Before data collection proper written consents were taken from all the participants. Along with the data regarding fibroids and vitamin D status, all the demographic and clinical data were collected and analyzed. In data collection, a predesigned questioner was used. All data were processed, analyzed and disseminated by using MS Excel and SPSS version 23.0 program as per necessity. Results: In this study, in assessing the fibroid’s sizes of several age group patients, between baseline and follow-up we found that, at baseline, in 20-30, 31-45 and >45 year’s age groups, the mean ±SD sizes of fibroids were 3.32±0.46, 3.91±0.50 and 4.05±0.51 cm respectively. On the other hand, at follow-up stage in those groups the mean ±SD sizes of fibroids were found as 2.64 ±0.40, 3.66±0.48 and 3.5±0.47 cm respectively. Finally, in evaluating the impact of vitamin D supplementation among our participants, comparing the fibroid sizes between baseline and follow-up stages, we observed that, in >45 years’ age group the fibroid size change was non-significant (P<0.05). ..

Introduction: The frequent and widespread use of imaging in clinical practice, particularly CT, has led to a steep increase in incidental ndings of asymptomatic solitary pulmonary nodules. In this situation, histocytopathological analysis is needed to conrm the diagnosis by CTguided biopsy / FNAC. So, the researcher purposively, designed this study. The aim of this study was to assess the outcomes of CT-Guided Fine-Needle Aspiration Cytology and Core Needle Biopsies of Solitary Lung Lesions. CT-uoroscopy guidance helps in this process by accurate needle positioning thus increase the success rate. Materials and Methods: This was a retrospective study conducted at the Department of Radiology & Imaging in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, during January 2017 to January 2019.Atotal of 270 patients who were referred to the Department of Radiology& Imaging for the evaluation of suspicious solitary lung lesions after the detection of a solitary pulmonary nodule in X-ray or CT scan, were included in this study. The results of CT uoroscopy–guided biopsy and FNAC for the included patients were analyzed to determine the diagnostic accuracy, complication rates, and independent risk factors for diagnostic failure and severe pneumothorax in this study. The factors related to the patients' solitary lesions, and procedures were evaluated by univariate analyses using the twosided Student t test for numeric values and Chi-squared test for categorical values where p<0.05 considered as signicant. Statistical analysis were performed using SPSS, version-23.0.Results: Diagnostic accuracy rate was 95.86%, failure was 4.14%, the overall sensitivity was 92.96%, specicity was 85.23% and the statistically signicant risk factors wereage (p=0.001), sex(p=0.001), smoking stats(p=0.001) emphysema(p=0.001),benign lesions(p=0.001),positioning of the patient for the procedure(p=0.001),location of the lesion(p=0.001) lesion size(p=0.001) pneumothorax (p=0.001) and length from the pleura to the lesion of 1.5 cm or greater,(p=0.001).Pneumothorax requiring drainage occurred in 1.48% of patients. The potential risk factors for pneumothorax requiring drainage were age of 73 years, the presence of emphysema, lesion size ≤ 2.0 cm and length from pleura to lesion of ≥ 1.5 cm. The major complications were being observed pneumothorax 15(5.63%), haemoptysis16 (6.01%), and hemothorax 03(1.12%).Conclusion: CT-Fluoroscopy Guided Fine-Needle Aspiration Cytology and biopsy has a high diagnostic accuracy; complication rates were acceptable and comparable to those of previous studies.

Background: Infective vertebral lesions usually involve the vertebral column, including the bone, intervertebral disk and paravertebral soft tissues. Variable imaging characteristics in conjunction with clinical findings can facilitate early diagnosis and treatment. MRI is a powerful imaging tool that can be help to evaluate spinal pathology specially infection. Typical MRI findings of infective vertebral disease are vertebral endplate destruction, bone marrow and intervertebral disc signal intensity changes and para vertebral soft tissue involvement. Objective: This study was aimed to assess whether the MRI can different the in differentiate the invective vertebral lesions from benign or malignant Tumors. Methods: This cross-sectional study was conducted on a total of 52 clinically suspected patients of infective vertebral lesions to establish diagnostic accuracy of MRI. The validity of MRI diagnosis for infective vertebral lesion was compared against CT-guided fine needle aspiration cytological (FNAC) diagnosis. Results: The sensitivity, specificity, positive and negative predictive values (PPVs and NPVs) and finally diagnostic accuracy of MRI were calculated by comparing the MRI diagnoses with those of fine needle aspiration cytological diagnosis of vertebral lesions. Finally the sensitivity, specificity, PPV and NPV of MRI diagnosis for infective vertebral lesion were 95.6%, 85.7%, 97.7% and 75.0% respectively. The overall diagnostic accuracy was 94.2%. Conclusion: Finding of this study suggested that MRI should be considered as the imaging modality of choice for patients with suspected infective vertebral lesions. Bangladesh Med Res Counc Bull 2020; 46(3): 233-239

Background: Alzheimer’s disease is the most common cause of dementia. Uric acid is the end product of purine metabolism in humans and acts as a natural antioxidant, accounting up to 60% of the free radical scavenging activity in human blood to prevent free radicals induced oxidative cell injury. This study aimed to explore the association between serum uric acid level and cognitive impairment of Alzheimer’s disease patients compared to those of the non-demented age and sex matched controls. Methods: This case control study was carried out in the department of neurology, BSMMU, Dhaka. Total 116 patients were enrolled as study population after satisfying inclusion and exclusion criteria. Among them, 58 were grouped as case and rest 58 were control. All blood samples for serum uric acid were measured in the Biochemistry lab, Department of Biochemistry, BSMMU, Dhaka. Results: A signiûcant reduction of serum uric acid levels in the AD group was found compared to those of the control group (4.35±1.59 Vs 6.89±1.68) which was statistically significant (p<0.001). We also found a positive correlation between serum uric acid levels with severity of Alzheimer’s disease (rp = 0.633, P<0.001). Among demographic variables educational qualification was statistically significant (p=0.006) in AD patients. Conclusion: This study showed that oxidative injuries have an important role in the pathogenesis of AD. Higher levels of uric acid are associated with a decreased risk of dementia and better cognitive function later in life. Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 83-88

Background: Alzheimer’s disease is a neurodegenerative disease. It is the most common cause of dementia in individuals older than 60 years of age. Age is the most important risk factor for Alzheimer’s disease. It is important to identify modifiable risk factors. One such important modifiable risk factor is Magnesium, a trace element. The objective of the study was to see the association of serum Magnesium concentration with Alzheimer’s disease patients. Method: It was a case control study carried out in neurology department of BSMMU, Dhaka. Total 68 patients were enrolled as study population after satisfying inclusion and exclusion criteria. Among them, 34 were grouped as case and rest 34 were control. Serum Magnesium concentration was detected. Result: Serum Magnesium concentration was significantly lower in AD patients than that of control group [2.04±0.19 mg/dl vs 2.36±0.21 mg/dl. Conclusion: The results of our study revealed an expression that the trace element, Magnesium concentration has an association with Alzheimer’s disease. Bangladesh Journal of Neuroscience 2017; Vol. 33 (2): 70-75