Childhood acute lymphoblastic leukemia is a genetically heterogeneous cancer that accounts for 10–15% of T-cell acute lymphoblastic leukemia (T-ALL) cases. The T-ALL event-free survival rate (EFS) is 85%. The evaluation of structural and numerical chromosomal changes is important for a comprehensive biological characterization of T-ALL, but there are currently no genetic prognostic markers. Despite chemotherapy regimens, steroids, and allogeneic transplantation, relapse is the main problem in children with T-ALL. Due to the development of high-throughput molecular methods, the ability to define subgroups of T-ALL has significantly improved in the last few years. The profiling of the gene expression of T-ALL has led to the identification of T-ALL subgroups, and it is important in determining prognostic factors and choosing an appropriate treatment. Novel therapies targeting molecular aberrations offer promise in achieving better first remission with the hope of preventing relapse. The employment of precisely targeted therapeutic approaches is expected to improve the cure of the disease and quality of life of patients. These include therapies that inhibit Notch1 activation (bortezomib), JAK inhibitors in ETP-ALL (ruxolitinib), BCL inhibitors (venetoclax), and anti-CD38 therapy (daratumumab). Chimeric antigen receptor T-cell therapy (CAR-T) is under investigation, but it requires further development and trials. Nelarabine-based regimens remain the standard for treating the relapse of T-ALL.

microRNA directly inhibit CD44 which suppresses prostatic cancer stem cells and its metastases. CSCs have high expression of programmed death-ligand 1 (PD-L1) including breast and colon cancer, which proclaims in favour of immunotherapy aimed on CSCs. Conclusions: Constantly growing knowledge about CSCs biology is creating new opportunities of detection, isolation and design of the therapies aimed on CSCs.

Introduction: Endometriosis is considered a chronic disease, which significantly worsens the quality of life of women suffering from it. So far, the pathogenesis has not been clarified, and therefore no causal treatment has been invented. A number of pharmacological substances are available, however, they are mainly classified as symptomatic treatment. Patients are looking for all kinds of therapies, including alternative ones, e.g. modification of diet and physical activity. Aim of the study: A review of current research on the pathogenesis of endometriosis, recommended forms of treatment, as well as the impact of individual nutrients and physical activity on the development and course of endometriosis. Material and method: The review covers publications published in 2018-2023. The search for publications in the Pubmed electronic database was carried out using the following keywords: endometriosis, treatment, diet, anti-inflammatory diet. Description of the state of knowledge: Most of the analyzed studies indicate the complexity of the pathogenesis of endometriosis, and therefore also the treatment. In addition, the literature has shown that substances such as vitamin D, curcumin, quercetin, resveratrol, polyunsaturated fatty acids and vitamins C and E, as well as physical activity, can have a positive impact on the development, severity of symptoms, and the quality of life of patients with endometriosis. Summary: The best forms of diagnosis and pharmacological and non-pharmacological treatment of endometriosis are sought. A number of medicinal substances are available, but they still do not allow patients to be cured. Studies show that modifying the diet and introducing individual nutrients can also have a positive effect on the course and treatment of endometriosis. It is necessary to conduct further studies evaluating the pathogenesis, methods of treatment of endometriosis, as well as the impact of lifestyle modifications on it.

Introduction: Lumbar spine pain is a common clinical problem. Due to the multitude of causes of pain, it is important to know the most common ones in order to choose an effective method of treatment.  The aim of this study: Summary of current knowledge regarding back pain caused by radiculopathy associated with lumbar stenosis.  Material and method: The review includes publications published in 1995-2020. The search of the publications in the Pubmed database was carried out using the following keywords: back pain, radiculopathy, lumbar stenosis. Description of the stage of the knowledge: Lumbar radiculopathy caused by lumbar stenosis is a common clinical problem, especially in older age groups. In diagnostics, an interview with the patient, physical examination and imaging tests - especially CT and MRI - are important. In most patients, conservative treatment is sufficient - the use of analgesics and anti-inflammatory drugs and physiotherapy. In justified cases, surgical treatment should be considered as the most effective causative treatment of the disease. In the last 20 years, the availability of both diagnostic methods has increased and new surgical techniques have appeared, aiming at minimally invasive treatment. Summary: Radiculopathy caused by lumbar stenosis is a contributing factor to the occurrence of pain, which can hinder the normal functioning of the patient.Proper diagnosis, identification of the impact and methods of treatment, both conservative and surgical, can help the patient and affect his quality of life. Early diagnosis and treatment are crucial for the effective treatment of pain associated with radiculopathy caused by lumbar stenosis.