A synthetic method for azaheterocycles from aryl ketone O-acetyl oximes and internal alkynes has been developed by using the Cu(OAc)(2)-[Cp*RhCl(2)](2) bimetallic catalytic system. The reactions proceeded with both of anti- and syn-isomers of oximes with a wide scope of substituents. The Cu-Rh bimetallic system could be applied for the synthesis of isoquinolines as well as β-carboline, furo[2.3-c]pyridine, pyrrolo[2,3-c]pyridine, and thieno[2,3-c]pyridine derivatives.

C h emIn fo rm 2 0 1 2 , 4 3 , issu e 1 0 © 2 0 1 2 Wiley -VCH Verl ag G m b H & Co. K G a A , We i n he i m Iso indole deriv ative s R 0140 DOI: 1 0.100 2/chin .2012 101 17 Synthesis of I soindo les via 1 ,3-D ipola r Cyclo addition of α-A zid o Ca r b o n yl C ompounds onto Intram olecular A lkenes and Their C o nvers io n into Substit u t ed A ro-matic Hydro carbons. -(TON G, B. M. K.; H UI, B . W.-Q .; CH UA , S. H .; C HI BA*, S.; Synth esis 2 011 , 21, 3 552-35 62, h ttp://dx.d oi.org/1 0.105 5/s-0 030-12 60221 ; Div . C he m . B iol. Che m., Sch. Phys. Ma t h. Sc i., Nan yang Te chno l. Univ., Sing apore 63 7371, Singa pore; Eng .) -Ma is

A method for the synthesis of oxymethyl dihydropyrroles (pyrrolines) and dihydroimidazoles has been developed via Cu(II)-mediated intramolecular aminooxygenation of alkenylimines and alkenylamidines, respectively, with 2,2,6,6-tetramethyl-1-piperidinyloxy radical (TEMPO).

a-Azido carbonyl compounds bearing a 2-alkenylaryl moiety in the a-position are found to be promising precursors in the synthesis of isoindoles via 1,3-dipolar cycloaddition of azides to alkenes. Applications of these isoindoles in the preparation of 1,2,3,4-tetrasubstituted naphthalene and 9,10-disubstituted anthracene derivatives were developed via [4+2]-cycloaddition reactions of isoindoles with dimethyl acetylenedicarboxylate and benzynes, respectively, followed by deaminative aromatization.

Cu(II)-Mediated Aminooxygenation of Alkenylimines and Alkenylamidines with TEMPO. -The process allows the preparation of dihydropyrrole and dihydroimidazole units bearing an oxymethyl function. -(SANJAYA, S.; CHUA, S. H.; CHIBA*, S.; Synlett 2012, 11, 1657-1661, http://dx.