Culturing of bone marrow cells in serum-free RPMI-1640 medium led to a decrease in the rate of DNA biosynthesis. Addition of HDL or their main protein component apolipoprotein A-I to the culture medium dose-dependently increased the rate of [3H]-thymidine incorporation into DNA. The maximum stimulation was achieved at HDL concentration of 80 μg/ml and apolipoprotein A-I concentration of 20 μg/ml. To identify the target-cells of apolipoprotein A-I, we used thymidine analogue 5-ethynyl-2'-deoxyuridine (EdU) that incorporates into cell DNA at the stage of replicative DNA synthesis (S phase) and can be detected by fluorescence microscopy. In bone marrow cell culture, apolipoprotein A-I stimulates the proliferation of monocyte (monoblasts, promonocytes) and granulocyte (myeloblasts, promyelocytes) progenitor cells, as well as bone marrow stromal cells.

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The development of biotechnology in the field of GMOs requires states to take specific decisions to regulate the spread of genetically modified crops. In the European Union all GM crops that circulation are subject to mandatory registration, which regulates the placing on the market and circulation of genetically modified raw materials, food and feed. The article presents systematized data about the registration of genetically modified soybean, maize and rapeseed in the European Union. It was established that most of the GM crops have introduced genes that give them tolerance to herbicides of different groups. The register of the European Union currently includes 12 events of soybean (GTS 40-3-2, A2704-12, Mon 89788, MON87705, DP 356043, A5547-127, FG 72, SYHTOH 2, DAS-44406-6, DAS-68416- 4, Mon 87708, BPS-CV127-9), 5 events of maize (MZHG0JG, DAS-40278-9, GA 21, NK 603, T 25), 3 events of rapeseed (GT 73, T45, TOPAS 19/2) with tolerance to herbicides. It has been shown that a significant number of registered GM plants have a combination of several events, including tolerance to herbicides and resistance to certain insects or improving quality features of crops. Among them are one event of soybean (DP305423-1), 9 events of maize (TC 1507, DP 4114-3, MON 87411-9, MON 87427, MON 88017, DAS59122-7, Bt 176, Bt 11, DAS 1507) and one event of rapeseed (MS8xRF3). Many GM crops (one event of soybean and 6 events of maize) have introduced genes that determine the plant's tolerance to insects. Only a tiny amount of GM crops are being with altered consumer or technological qualities. In the register of genetically modified crops, all events of GM crops are currently authorized for usage for food, supplements, feed and other product. А single event of maize (Mon 810), that was allowed for cultivation at the time of this analysis was at the stage of renewal of the permit.

Die syn‐ (I) und anti‐Isomeren (II) der Naphthylhydrazone von Brenztraubensäure und einigen ihrer Ester werden auf üblichem Wege dargestellt bzw. isoliert und IR‐, UV‐ sowie H‐NMR‐spektrometrisch charakterisiert.