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intense hyperemia following the application of radium, with the patient still in the hospital, that a month later there will be considerable slough. Later, granulations form And, also, we are skeptical of the value of observations that manifest so great a variability; for when we exam¬ ine consecutive collections of urine from a patient we may find in one specimen many casts and red blood cells and in the next, few or none. It is probably this incon¬ stancy that has led those who in our day have most studied Bright's disease to the opinion that in the past the value of the microscopic examination of the urine was overemphasized. Yet the idea that we might learn something important from a systematic and con-