An efficacious, metal-free
strategy has been developed for the
synthesis of 4-aryl-3-(2H)-furanones. The reaction
proceeds via the nucleophilic addition of an active methylene compound
to the aryne followed by ring closing of the adduct. The reaction
proceeds under mild conditions, is applicable for gram-scale synthesis
of 4-aryl-3-(2H)-furanones, and is general for a
range of substituted arynes and haloacetates.
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