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<b>Introduction.</b> Comorbid patients represent one of the most vulnerable groups with an extremely high risk of severe complications and adverse outcomes of COVID-19. Multiple organ damage in COVID-19 is associated with pathology of the cardiovascular system, diabetes mellitus, chronic obstructive pulmonary disease, chronic inflammatory bowel disease, and liver disease. The management of these patients requires an integrated approach, and therefore the need for optimal nutritional support is essential. <b>Materials and methods.</b> 36 patients with comorbid pathology with a history of COVID-19 (10-70% of lung involvement) 1.5-12 months prior to the study were examined. The metabolic and clinical status of patients was assessed using general clinical, laboratory and functional (bioelectrical impedance) research methods. <b>Results.</b> The analysis showed an increased rate of fat oxidation, a decrease in the rate of carbohydrate oxidation, and the absence of significant changes in the rate of protein oxidation. <b>Conclusion.</b> The data obtained are of practical importance for the development of recommendations and correction of the nutritional status of this group of patients.

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