Background and aims: Despite the increased rates of acute kidney injury (AKI) in intensive care units (ICU) and associated mortality, information on the epidemiology of AKI is sparse in sub-Saharan Africa (SSA). We investigated the rates and predictors of AKI and associated mortality in a tertiary ICU. Materials and methods: This retrospective study analyzed 280 hospital records of patients admitted to the ICU at a tertiary teaching hospital who were aged ≥15 years from January 2017 to May 31, 2018. The outcome parameters of the study were rates of AKI in the ICU, associated risk factors, and mortalities. Acute kidney injury and ICU mortality were established by the multivariate logistic analysis. Results: The median age was 36 years (IQR 28, 52). The rate of AKI was 52.9%, and the presence of human immunodeficiency virus (HIV) and oliguria was 2.3-fold (0.004) and 4-fold (0.016) positive predictors of ICU-AKI, respectively. Male gender (0.003), diabetes mellitus (DM) (0.010), respiratory disease (0.001), inotropes (0.004), and ventilator support (0.017) were predictors for ICU mortality after controlling for confounders. Conclusion:The rate of AKI is significantly higher in a referral tertiary hospital in Zambia compared to developed countries and the presence of HIV and noncommunicable diseases such as DM impacts severely on outcomes.

Introduction: Dialysis is the primary kidney replacement therapy for patients with kidney failure in sub-Saharan Africa. We assessed the rates and predictors of early mortality in Zambian patients starting chronic dialysis. Methods: This retrospective study included all patients who started chronic haemodialysis (HD) or peritonealdialysis (PD) between 1 January 2017 and 31 August 2020 at the three largest public dialysis centres in Zambia. Data on clinical, laboratory and dialysis characteristics were extracted from medical records. The primary outcome of interest was the mortality rate at 90 days. Results: A total of 154 patients were included in the study; 43.5% were female and 32% were 50 years or older.The main causes of kidney failure were hypertension (59%), glomerulonephritis (10%), HIV/AIDS (10%) andunknown (8%). The mortality rate at 90 days was 12.3%. Of these, 42% were cardiovascular-related mortalities and 32% died of infection related to central venous catheters. The lymphocyte percentage of total white blood cells was lower in patients who died compared to survivors (12.7 vs 20.8%) and was an independent predictor of early mortality (OR 0.914, 95% CI 0.850–0.983; P = 0.015). Conclusions: Early mortality was high in Zambian patients starting dialysis, and a low lymphocyte percentage was a predictor of mortality.

No abstract

month mortality (1 study). Conversely, in the largest study found, and the only to include a non-AKI comparator group, BMI did not modify the risk of mortality 1-year post-AKI. Variations in length of follow-up, study design, analysis methods, and definitions of AKI and renal recovery precluded meta-analysis. Conclusions: The limited evidence suggests that BMI may not influence 90-day renal recovery; however, the impact of BMI on CKD incidence and progression outcomes remain unknown. Findings suggest that a higher BMI may have a beneficial effect on survival after an episode of AKI at 90 days and 6 months though not at 1 year, suggesting the length of follow-up is critical in determining the effect of BMI on survival. Future AKI studies should report BMI to determine if it contributes to the adverse long-term consequences of AKI.

Emirates (UAE). Ministry of Health plays a central role in the health status of the citizens and residents. Health data are collected routinely as a part of the mandatory requirement from all around the country including end-stage kidney disease (ESKD) data like the United States Renal Data System (USRDS). Continuous improvement in registries is required to improve capturing of ESKD patients for providing accurate data to health authorities and enhancing public awareness of the magnitude. Hereby, we examine the causes, progression, and magnitude of endstage kidney disease (ESKD) over the last almost forty years in Oman. Methods: We examined ESKD data from 1983 to 2020. A questionnaire based on USRDS form 2728 is regularly completed by nephrologists once a citizen reached ESKD and then received by central office in Muscat, the capital city. The data entered are rechecked by 2 other team members. Data were analyzed using STATA software (Stata Corporation, College Station, TX). Results: So far, a total of 5385 forms were completed, with a response rate of 92% (52.6% males). The mean (SD) age was 50.3 (14.0) years. By the 15 th of October 2019, there were 4117 patients alive on renal replacement therapy (RRT); of whom 2040 were on hemodialysis (49.5%), 1860 were living with a functioning kidney transplant (45.1%), and 217 were receiving peritoneal dialysis (5.2%).