Both BTFC dosing regimens significantly reduce 24 h IOP in XFG compared with bimatoprost monotherapy. The evening dosing gives rise to statistically better 24 h IOP control and could be considered in these patients.

Purpose To evaluate 24-h efficacy of travoprost/timolol fixed combination (TTFC) vs latanoprost/timolol fixed combination (LTFC) in exfoliative glaucoma (XFG). Design A prospective, single-masked, crossover, active-controlled, randomized 24-h comparison. Methods After up to a 6-week medicine-free period, XFG patients were randomized to either TTFC or LTFC for 3 months, dosed each evening, and then changed to the opposite treatment for another 3 months. At the end of the washout, and both treatment periods, a 24-h intraocular pressure (IOP) curve was measured.