At the end of this time the tumor in each animal occupied the whole abdominal area. There was no ulceration or discharge. The 6 animals were killed and at autopsy no metastases were found. The tumor in each control animal was highly vascular and no necrotic areas were observed. In each experimental rat the tumor consisted of a thin layer of active sarcomatous tissue which surrounded an extensive central area containing a large amount of hemorrhagic fluid.Conclusions. These data indicate that cobra venom is a destructive agent for the cells of the Fujinami rat sarcoma, (but its therapeutic value is limited because of its localized action on the tumor cells, leaving the unaffected cells free to grow at a rapid rate. PEffect of Intracisternal Injections of Acetylcholine.

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